[#1998-02] Adjuvant Effect of Grifolan o...

Adjuvant Effect of Grifolan on Antibody Production in Mice Yoshiyuki ADACHI, Yoko SUZUKI, Naohito OHNO, and Toshiro YADOMAE* Laboratory of Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Japan. The effects of grifolan (GRN from maitake ), a gel-forming (1—>6)-branched (1—>3)-β-glucan, on antibody production were examined. Sera from mice that were injected with GRN and trinitrophenyl ovalbumin (TNP-OVA) in­traperitoneally showed a significantly increased level of anti-TNP IgG. However, injection of...

[#1997-08] Effects of Lentinus edodes, G...

Effects of Lentinus edodes, Grifola frondosa and Pleurotus ostreatus administration on cancer outbreak, and activities of macrophages and lymphocytes in mice treated with a carcinogen, N-butyl-N-butanolnitrosoamine Kurashige S, Akuzawa Y, Endo F. Department of Laboratory Sciences, Gunma University School of Health Sciences ICR mice were treated with a carcinogen, N-butyl-N’-butanolnitrosoamine (BBN), every day for 8 consecutive weeks and the effects of oral administration of edible mushrooms on the induction of urinary bladder carcinoma and on the activities of...

[#1997-06] Anti-hyperliposis effect of m...

Anti-hyperliposis effect of maitake fruit body (Grifola frondosa) Kubo K, Nanba H. Department of Microbial Chemistry, Kobe Pharmaceutical University Experimental rat models (5-week-old Sprague-Dawley rats) with hyperlipemia were prepared by feeding high-cholesterol feed containing sodium cholate and casein as a protein source. Dried maitake (Grifola frondosa) powder was mixed with the basic high-cholesterol feed and the serum lipids were periodically measured. Values of cholesterol, triglyceride and phospholipid in serum of rats in the maitake-feed group were suppressed by...

[#1997-05] Sterol Constituents from the ...

Sterol Constituents from the Fruit Bodies of Grifola frondosa Ishizuka, T, Yaoita, Y, Kikuchi, M Tohoku College of Pharmacy Four new sterols, 5α, 6α-epoxy-(22E, 24R)-ergosta-8 (14), 22-diene-3β, 7β-diol (1), (22E, 24R)-ergosta – 8,22-diene-3β,5α,6β,7α-tetrol (2), (22E,24R)-ergosta-7,9(11), 22-triene-3β,5α,6β-triol (3) and 3β,5α,6β-trihydroxy-(22E,24R)-ergost-22-en-7-one (4), have been isolated from the fruit bodies of Grifola frondosa ( maitake ) together with fourteen known ones (5-18), of which two (5 and 6) are reported for the first time from a...

[#1997-04] Nitric Oxide Synthesis in Mur...

Nitric Oxide Synthesis in Murine Peritoneal Macrophages by Fungal β-Glucans Tomoe HASHIMOTO, Naohito OHNO, Yoshiyuki ADACHI, and Toshiro YADOMAE* Maitake Laboratory of Immunopharmacology of Microbial Products, Tokyo University of Pharmacy and Life Science, Japan. Fungal β-glucans have abilities to induce NO (nitric oxide) synthesis by macrophages in vivo, and the intensity of NO synthesis significantly varied dependent on the structure of β-glucans. The molecular mechanism of NO synthesis by β-glucans, however, has not been clarified in detail. To determine...

[#1997-03] Effect of Maitake D-Fraction ...

Effect of Maitake D-Fraction on Cancer Prevention Nanba, H  Kubo, K Department of Microbial Chemistry, Kobe Pharmaceutical University In this paper, the author investigates whether D-fraction is effective against chemically-induced cancer and against metastasis or recrudescence of MM-46 breast cancer. The known carcinogen, methylcholanthrene, was injected into mice. Subsequently, D-fraction or saline was administered. In the D-fraction-treated mice, carcinogenesis occurred in 31% of cases relative to 93% of cases in the control. In a similar experiment, tumor metastasis...