[#1995-08] Effects of Administration of ...

Effects of Administration of Grifola frondosa on Glucose Tolerance and Glucosuria in Rats with Experimental Diabetes Horio, H(a), Ohtsuru, M(b) a) Department of Nutrition, Faculty of Home Economics, Yamaguchi Women’s University, b) Department of Food and Nutrition, School of Human Life and Environmental Sciences, Mukogawa Women’s University The effects of Maitake (Grifola frondosa) on blood glucose levels in rats with streptozotocin-induced diabetes were investigated. Diabetic rats were produced by injecting 80 mg/kg streptozotocin into 2-day-old neonates. From...

[#1995-07] Antitumor Activity in Mice by...

Antitumor Activity in Mice by β-Glucan Obtained from Grifola frondosa (Maitake) Adachi, K, Nanba, H, Kuroda, H Department of Microbiology, Kobe Women’s College of Pharmacy A polysaccharide (3-branched β-1,6-glucan MT-2) extracted from fruit bodies of Grifola frondosa ( Maitake ) showed an antitumor effect against mouse syngeneic tumors (MM-46 carcinoma and IMC-carcinoma). It not only directly activates various effector cells (microphages, natural killer cells, killer T cells, etc.) to attack tumor cells, but also potentiates the activities of various mediators...

[#1995-06] Results of Non-Controlled Cli...

Results of Non-Controlled Clinical Study for Various Cancer Patients Using Maitake D-Fraction Nanba, H Department of Microbial Chemistry, Kobe Pharmaceutical University A non-randomized clinical study using D-fraction and Maitake crude tablets was conducted to investigate if those are effective against cancer patients as they were against animals. The study was carried out with 165 patients with advanced cancer, stage III-IV, 25-65 years old. Most of the patients receiving the Maitake treatment claimed improvement of overall symptoms. The highest response rates were seen...

[#1995-05] Structure-activity relationsh...

Structure-activity relationship of (1->3)-β-D-glucans in the induction of cytokine production from macrophages, in vitro Okazaki M, Adachi Y, Ohno N, Yadomae T. Laboratory of Immunopharmacology of Microbial Products School of Pharmacy, Tokyo University of Pharmacy and Life Science In a previous study, we reported that one of the gel-forming (1->3)-β-D-glucans, grifolan (from Maitake  Grifola frondosa, GRN), stimulated cytokine production from macrophages in vitro. However, several other gel-forming (1->3)-β-D-glucans, such as sonifilan (SPG) and SSG, did not...

[#1995-04] Maitake: Grifolan-Ohno, Naohi...

Enhancement of LPS triggered TNF-α (tumor necrosis factor-α) production by (1->3)-β-D-glucans in mice Ohno N, Asada N, Adachi Y, Yadomae T. Tokyo College of Pharmacy Effects of (1->3)-β-D-glucans on tumor necrosis factor-α (TNF-α ) production in mice in vivo were investigated with or without triggering stimulation of lipopolysaccharide (LPS). Administration of grifolan (GRN) (100-250 μg/mouse) obtained from Grifola frondosa ( maitake ), did not elevate the TNF-α concentration in serum, but significantly elevated LPS (10 μg/mouse)-elicited TNF-α...

[#1995-03] Characterization of a Thermos...

Characterization of a Thermostable Lysine-Specific Metalloendereptidase from the Fruiting Bodies of a Basidiomycete, Grifola frondosa Takashi Nonaka, Hiroko Ishikawa, Yoichi Tsumuraya, Yohichi Hashimoto, Naoshi Dohmae, and Koji Takio Department of Biochemistry, Faculty of Science, Saitama University, Saitama, Japan; and Division of Biomolecular Characterization, The Institute of Physical and Chemical Research (RIKEN), Saitama, Japan   A zinc-metalloendopeptidase, MEP, capable of catalyzing specific cleavage of acyl-lysine bonds (-X-Lys-) in polypeptides has been...