[#1996-04] The effect of maitake mushroo...

The effect of maitake mushrooms on liver and serum lipids Kubo K, Nanba H. Department of Microbial Chemistry, Kobe Pharmaceutical University OBJECTIVE: To determine the efficacy of maitake mushrooms in inhibiting the elevation of liver and serum lipids in rats.  DESIGN: Sprague-Dawley rats with hyperlipidemia were used to measure and compare the values of cholesterol, phospholipids, and triglycerides between cholesterol-fed rats and rats whose diets were fortified with 20% maitake mushroom dried powder.  RESULTS: The values in maitake-fed rats were consistently less than...

[#1996-02] Effect of beta-glucans on the...

Effect of beta-glucans on the nitric oxide synthesis by peritoneal macrophage in mice Ohno N, Egawa Y, Hashimoto T, Adachi Y, Yadomae T. School of Pharmacy, Tokyo University Pharmacy and Life Science, Japan. Nitric oxide (NO) is an important effector molecule on antimicrobial and antitumor effects of macrophages. (1 -> 3)-β-D-Glucan (β-glucan) is well known to show various immunopharmacological effects such as antimicrobial effect and antitumor effect by activating various points of host defense mechanisms. This paper deals with NO synthetic activity of peritoneal...

[#1996-01] Blood clearance of (1->3)-β-D...

Blood clearance of (1->3)-β-D-glucan in MRL lpr/lpr mice Miura NN, Ohno N, Aketagawa J, Tamura H, Tanaka S, Yadomae T. Laboratory for Immunopharmacology of Microbial Products, Tokyo University of Pharmacy and Life Science (1->3)-β-D-Glucans have a variety of biological and immunopharmacological properties, and they are used clinically as biological response modifiers (BRMs). Clinically, these glucans have often been used for long periods by multiple dosing. During studies on the clearance and metabolism of the glucans in mice, we have found that, in the case of a...

[#1995-08] Effects of Administration of ...

Effects of Administration of Grifola frondosa on Glucose Tolerance and Glucosuria in Rats with Experimental Diabetes Horio, H(a), Ohtsuru, M(b) a) Department of Nutrition, Faculty of Home Economics, Yamaguchi Women’s University, b) Department of Food and Nutrition, School of Human Life and Environmental Sciences, Mukogawa Women’s University The effects of Maitake (Grifola frondosa) on blood glucose levels in rats with streptozotocin-induced diabetes were investigated. Diabetic rats were produced by injecting 80 mg/kg streptozotocin into 2-day-old neonates. From...

[#1995-07] Antitumor Activity in Mice by...

Antitumor Activity in Mice by β-Glucan Obtained from Grifola frondosa (Maitake) Adachi, K, Nanba, H, Kuroda, H Department of Microbiology, Kobe Women’s College of Pharmacy A polysaccharide (3-branched β-1,6-glucan MT-2) extracted from fruit bodies of Grifola frondosa ( Maitake ) showed an antitumor effect against mouse syngeneic tumors (MM-46 carcinoma and IMC-carcinoma). It not only directly activates various effector cells (microphages, natural killer cells, killer T cells, etc.) to attack tumor cells, but also potentiates the activities of various mediators...

[#1995-06] Results of Non-Controlled Cli...

Results of Non-Controlled Clinical Study for Various Cancer Patients Using Maitake D-Fraction Nanba, H Department of Microbial Chemistry, Kobe Pharmaceutical University A non-randomized clinical study using D-fraction and Maitake crude tablets was conducted to investigate if those are effective against cancer patients as they were against animals. The study was carried out with 165 patients with advanced cancer, stage III-IV, 25-65 years old. Most of the patients receiving the Maitake treatment claimed improvement of overall symptoms. The highest response rates were seen...