[#1989-02] Modulation of Antitumor Activ...

Modulation of Antitumor Activity of Grifolan by Subsequent Administration of (1–>3)-β-D-Glucanase in Vivo Isao NONO, Naohito OHNO,* Masumi OHSAWA, Shozo OIKAWA and Toshiro YADOMAE Laboratory of Immunopharmacology of Microbial Products, Tokyo College of Pharmacy,  Horinouchi,Hachioji, Tokyo, 192-03, Japan and Nippon Beet Sugar Mfg., Co., Ltd.,  Chuo-ku, Tokyo, 104, Japan The initiation process of effector mechanism of the antitumor activity of (1–>3)-β-D-glucans has been examined in detail by applying treatment of mice with...

[#1989-01] Maitake – Physiochemic...

Maitake  - Physiochemical properties and antitumor activities of chemically modified derivatives of antitumor glucan “grifolan LE” from Grifola frondosa Adachi Y, Ohno N, Ohsawa M, Sato K, Oikawa S, Yadomae T. Laboratory of Immunopharmacology of Microbial Products, Tokyo College of Pharmacy Antitumor glucan, grifolan LE (GRN LE), from Grifola frondosa ( maitake ) was chemically modified to examine the structure-function relationship of the products. Modification by periodate, borohydride and acid hydrolysis of side chains of GRN LE did not alter properties...

[#1988-03] Distribution of Grifolan NMF-...

Distribution of Grifolan NMF-5N (I/B), a Chemically Modified Antitumor β- Glucan in Mice Takahiro TAKEYAMA, Iwao SUZUKI, Naohito OHNO,* Shozo OIKAWA, Kichiro SATO, Masumi OHSAWA,** and Toshiro YADOMAE* Tokyo College of Pharmacy, * Horinouchi, Hachioji, Tokyo, 192-03, Japan and Nippon Beet Sugar Mfg., Co., Ltd., ** Chuo-ku, Tokyo, 104, Japan   The distribution of a 3H-labeled chemically modified antitumor β-glucan, grifolan ( from maitake ) NMF-5N (I/B), in various tissues after an injection into mice was examined in order to obtain information on distribution of the...

[#1988-02] Antitumor Activity Exhibited ...

Antitumor Activity Exhibited by Orally Administered Extract from Fruit Body of Grifola frondosa (Maitake) Hishida, I, Nanba, H, Kuroda, H Laboratory of Microbiology, Kobe Women’s College of Pharmacy, Japan The acid-insoluble, alkali-soluble, hot water-extractable polymer (a polysaccharide containing approximately 30% of protein; D-fraction) obtained from the fruit bodies of Grifola frondosa ( maitake ) exhibited antitumor activities against allogenic and syngeneic tumors on oral administration to mice. Winn assay conducted to examine the tumor growth-suppressing...

[#1988-01] Blood Pressure-Lowering Activ...

Blood Pressure-Lowering Activity Present in the Fruit Body of Grifola frondosa (Maitake) Adachi, K, Nanba, H, Otsuka, M, Kuroda, H Department of Microbiology, Kobe Women’s College of Pharmacy The fruit body of Grifola frondosa (maitake), Basidiomycetes, was confirmed to contain a substance with blood pressure-lowering activity. When powdered fruit body of maitake was given orally to spontaneously hypertensive rats (SHR), blood pressure reduction was observed, in contrast to the control group in which the blood pressure increased with aging. Ether-soluble (ES) and hot...

[#1987-09] Effect of Shiitake (Lentinus ...

Effect of Shiitake (Lentinus edodes) and Maitake (Grifola frondosa) Mushrooms on Blood Pressure and Plasma Lipids of Spontaneously Hypertensive Rats Kabir, Y, Yamaguchi, M, Kimura, S Laboratory of Nutrition, Department of Food Chemistry, Tohoku University To study the effect of Shiitake (Lentinus edodes) and Maitake (Grifola frondosa) on hypertension, spontaneously hypertensive rats were fed a diet containing 5% mushroom powder and 0.5% NaCl solution as drinking water for 9 weeks. The dietary mushrooms decreased the blood pressure. The plasma free cholesterol level...