[[#1987-05] Conformational Changes of th...

Conformational Changes of the Two Different Conformers of Grifolan in Sodium Hydroxide, Urea or Dimethylsulfoxide Solution Ohno, N (a), Adachi, Y(a), Ohsawa, M (b), Sato, K (b),Oikawa, S (b), Yadomae, T (b) a) Tokyo College of Pharmacy, b) Nippon Beet Sugar Mfg. Co. Ltd. Grifolan is an antitumor (1–>3)-β-D-glucan with a β-glucosyl substitution at C-6 of every three main chain units, and is produced by Grifola frondosa ( maitake ). Grifolan possesses two different solid-state conformations, N (native) and H (helix) (N. Ohno et al., Chem. Pharm. Bull. 34, 2555...

[#1987-04] Conformation of Grifolan in t...

Conformation of Grifolan in the Fruit Body of Grifola frondosa Assessed by Carbon-13 Cross Polarization—Magic Angle Spinning Nuclear Magnetic Resonance Spectroscopy NAOHITO OHNO,a MASUMI OHSAWA,b KICHIRO SATO,b SHOZO 01KAWA,b and TOSHIRO YADOMAE*‘b Tokyo College of Pharmacy,” Horinoudri. Hachiofi, Tokyo 192-03, Japan and Nippon Beer Sugar Mfg. Co., Ltd.,’ Kyobashi, Chuo-ku, Tokyo 104. Japan Grifola frondosa ( maitake ) produces an antitumor (1–>3)-β-D-glucan, grifolan, which possesses two kinds of conformations in the solid state, i.e.,...

[#1987-03] Effect of Grifolan on the Asc...

Effect of Grifolan on the Ascites Form of Sarcoma 180 NAOHITO OHNO,b YOSHIYUKI SUZUKI,b KICHIRO SATO,bSHOZO OIKAWA,b and TOSHIRO YADOMAO’b Tokyo College of Pharmacy,’ Horinouchi, Hachioji, Tokyo 192-03, Japan and Nippon Beet Sugar Mfg. Co., Ltd.,’ Kyobashi, Chuo-ku, Tokyo 104, Japan The antitumor activity of a (1–>3)-β-D-glucan, grifolan from Maitake , which was obtained from a fungus, Grifola frondosa, on the ascites form of Sarcoma 180 in ICR mice was examined. Grifolan was effective on the ascites tumor when it was administered before tumor...

[#1987-02] Potentiation of Host-Mediated...

Potentiation of Host-Mediated Antitumor Activity in Mice by Beta-Glucan Obtained from Grifola frondosa (Maitake) Adachi, K, Nanba, H, Kuroda, H Department of Microbiology, Kobe Women’s College of Pharmacy A polysaccharide (3-branched β-1,6-glucan MT-2) extracted from fruit bodies of Grifola frondosa ( maitake ) showed an antitumor effect against mouse syngeneic tumors (MM-46 carcinoma and IMC-carcinoma). It not only directly activates various effector cells (macrophages, Natural Killer cells, killer T-cells, etc.) to attack tumor cells, but also potentiates the...

[#1987-01] The Chemical Structure of an ...

The Chemical Structure of an Antitumor Polysaccharide in Fruit Bodies of Grifola frondosa (Maitake) Nanba, H, Hamaguchi, A, Kuroda, H Laboratory of Microbiology, Kobe Women’s College of Pharmacy A polysaccharide was extracted from fruit bodies of Grifola frondosa ( maitake ), and the chemical structure and antitumor activity was studied. The extracted polysaccharide could be hydrolyzed by beta-glucanase into glucose, indicating it to be a beta-glucan. The sample gave methyl 2,3,4,6-tetra-O-methyl 2,4,6-tri-O-, methyl2,3,4-tri-O- and methyl 2,4-di-O-methylglucoside in...

[#1986-09] Maitake: Ohno, Naohito et al ...

Effect of Activation or Blockade of the Phagocytic System on the Antitumor Activity of Grifolan NAOHITO OHNO,a MAMI HAYASHI,a IWAO SUZUKI,a SHOZO OIKAWA,b KICHIRO SATO,b YOSHIYUKI Suzum,b and TOSHIRO YADOMAE” Tokyo College of Pharmacy,’ Horinouchi, Hachioji, Tokyo 192-03, Japan and Nippon Beet Sugar Mfg., Co., Ltd.,”Chuo-ku, Tokyo 104, Japan The effect of activation or blockade of the phagocytic system on the antitumor activity of grifolan (from maitake ) was investigated. The activity of grifolan was abrogated by treatment of mice with a blocker of the...