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BIORESEARCH UPDATE NEWSLETTER #7 Patent ...

April 3, 2013 Amycenone®, a proprietary extract developed from a mushroom called Lion’s Mane (Hericium erinaceus), has been awarded a patent in Japan.  Its patent in the U.S. is pending. Amyloban®3399, a dietary supplement containing Amycenone® as an active ingredient, has been widely used and a number of clinical cases have also been reported for its role in certain conditions such as benign or mild dementia, snoring, sleep apnea, low quality of sleeping, juvenile apathy syndrome and schizophrenia.  Presentations on its clinical and laboratory studies have been...
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[#2012-04] Lion’s Mane Inanaga, Ka...

The current paper describes the physiological and nootropic actions of Amycenone, which is an activator of brain function that is obtained from extracts of the Yamabushitake (Hericium erinaceum). Kawagishi and his group have studied compounds that are derived from medicinal mushrooms and their use in the treatment of dementia since 1991. They have found that H. erinaceum exerts important bioactivities, including the induction of nerve growth factor (NGF) synthesis, the inhibition of the cytotoxicity of beta-amyloid peptide, and the protection against neuronal cell death...
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BIORESEARCH UPDATE NEWS LETTER #1 Medici...

  Medicinal Mushrooms  For OPTIMUM HEALTH AND LONGEVITY  Ken Babal, C.N. We all know that vitamin and mineral supplements can augment diets by providing essential nutrients that ward off disease. Likewise, botanicals can help us stay well, and can be used medicinally. There is yet a third category that ranks high for cultivating optimum health and resistance to disease. This is the mushroom category. Mushrooms are members of the fungal family, sometimes referred to as the third kingdom. Being neither plant nor animal, they possess highly unique characteristics that...
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[#2008-03] Compounds for dementia from H...

Compounds for dementia from Hericium erinaceum.   Kawagishi, Hirokazu and Zhuang, Cun Abstract Our group has been conducting a search for com­pounds for dementia derived from medicinal mush­rooms since 1991. A series of benzyl alcohol deriva­tives (named hericenones C to H), as well as a series of diterpenoid derivatives (named erinacines A to I) were isolated from the mushroom Hericium erinaceum. These compounds significantly induced the synthesis of nerve growth factor (NGF) in vitro and in vivo. In a recent study, dilinoleoyl-phosphatidylethanolamine (DLPE) was...
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[#2006-01] Lion’s Mane Nagai, Kaor...

Dilinoleoyl-phosphatidylethanolamine from Hericium erinaceum protects against ER stress-dependent Neuronal cell death via protein kinase C pathway Kaoru Nagai a,*, Akiko Chibab, Toru Nishinoa, Takeo Kubotaa, Hirokazu Kawagishib,* aDepartment of Epigenetic Medicine, Interdisciplinary Graduate School ofMedicine and Engineering, University of Yamanashi, Yamanashi 409-3898, Japan bDepartment of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, Shizuoka 422-8529, Japan Abstract In many types of neurodegeneration, neuronal cell death is induced by...