REFERENCES

[#2017-05] Maitake Zhang, Yizhi et al. Grifola frondosa polysaccharides induce breast cancer cell apoptosis via the mitochondrial-dependent apoptotic pathway

Grifola frondosa, a type of food and medical fungus, has been shown to exhibit various pharmacological activities, including anticancer effects. As the most typical cancer diagnosed among female patients, breast cancer remains a huge concern threatening human health globally. In the present study, the anti-breast cancer effects of Grifola frondosa polysaccharides (GFPs) and the underlying mechanisms were investigated in MCF-7 and MDA-MB-231 cells, as well as in nude mice bearing MCF-7 tumor xenografts. GFPs exerted cytotoxic effects on the...

read more

[#2017-04] Royal Agaricus Gobi, Veerapan Venkatesh et al. Agaricus blazei extract abrogates rotenone-induced dopamine depletion

Neuroinflammation and oxidative damage are the two main malfactors that play an important role in the pathogenesis of experimental and clinical Parkinson’s disease (PD). The current study was aimed to study the possible anti-oxidant and anti-inflammatory effects of the methanolic extract of Agaricus blazei (A.  blazei) against rotenone-induced PD in mice. Male Albino mice were randomized and divided into the following groups: control, treated with rotenone (1 mg/kg/day), co-treated with rotenone and A. blazei (50, 100, and 200 mg/kg...

read more

[#2017-03] Maitake Alonso, Eliana Noelia et al. Antitumoral Effects of D Fraction from Grifola Frondosa Maitake Mushroom in Breast Cancer (1)

D-Fraction is protein-bound b-1,6 and b-1,3 glucans (proteoglucan) extracted from the edible and medicinal mushroom Grifola frondosa (Maitake). The antitumoral effect of D-Fraction has long been exclusively attributed to their immunostimulatory capacity. However, in recent years increasing evidence showed that D-Fraction directly affects the viability of canine and human tumor cells, independent of the immune system. Previously, we have reported that D-Fraction modulates the expression of genes associated with cell proliferation, cell...

read more

[#2017-02] Maitake He, Xirui et al. Polysaccharides in Grifola frondosa mushroom and their health promoting properties, A review

Grifola frondosa is a widely consumed edible and medicinal fungus, Ancient books record that it can boost qi and fortify the spleen, moisten the lung and protect the liver. Modern people mainly use it to assist in the treatment of diabetes mellitus and various cancers. Over the past three decades, G. frondosa polysaccharides were shown to possess various promising bioactivities, mainly including anti-tumor and immunomodulation, anti-oxidation, anti-hyperglycemia, and meanwhile can effectively act on the skin and hematopoietic stem cells. The...

read more

[#2017-01] Lion’s Mane Phan, Chia-Wei et al Edible and Medicinal Mushrooms – Emerging Brain Food for the Mitigation of Neurodegenerative Diseases

There is an exponential increase in dementia in old age at a global level because of increasing life expectancy. The prevalence of neurodegenerative diseases such as dementia and Alzheimer’s disease (AD) will continue to rise steadily, and is expected to reach 42 million cases worldwide in 2020. Despite the advancement of medication, the management of these diseases remains largely ineffective. Therefore, it is vital to explore novel nature-based nutraceuticals to mitigate AD and other age-related neurodegenerative disorders. Mushrooms...

read more

[#2016-09] Meshima Konno, Sensuke et al. Alternative Therapeutic Approach to Urothelial Cell Carcinoma with Medicinal Mushroom Extracts

Abstract Severe side effects from chemotherapy or immunotherapy often limit their clinical utility in urothelial cell carcinoma of the bladder. To explore alternative therapies, we were particularly interested in one of medicinal mushrooms called Phellinus linteus (PL) with antitumor/anticancer activity. We investigated possible anticancer effects of three distinct extracts or fractions of PL using an urothelial cell carcinoma (UCC) model in vitro. Those fractions included PL-I (crude extract), PL-II (water-extracted), and PL-III...

read more

[#2016-08] Maitake Bao, Hongkun et al. Grifola frondosa GF produces significant antidepressant effects involving AMPA receptor activation in mice

In this paper, we investigated the antidepressant effects of the medical mushroom GF. We found that (1) GF demonstrated antidepressant effects in the TST and FST after 1-day or 5-day treatments; (2) GF led to no hyperactive effects in the OFT; (3)  The antidepressant effects of GF were stronger compared to the other medical mushroom PO; (4) AMPA receptor-specific antagonist GYKI 52466 was able to block the antidepressant effects of GF, suggesting that AMPA receptors are involved in the antidepressant effects of GF.

read more

[#2016-07] Poria Konno, Sensuke et al. Antioxidant and Renoprotective Effects of Mushroom Extract; Implication in Prevention of Nephrolithiasis

The present study shows that PE has antioxidant and renoprotective effects against severe oxidative stress exerted by H2O2 or COM (CaOx monohydrate). Such oxidative stress would inhibit glycolysis, deplete cellular ATP, and also interfere with the cell cycle progression (a G1 cell cycle arrest). These adverse effects may account for the resulting cell viability reduction but could be effectively prevented by PE. Therefore, PE is a promising agent with antioxidant activity, capable of protecting renal cells from oxidative assault, and...

read more

[#2016-04] Royal Agaricus Therkelsen, S. P. et al. Effect of the Medicinal Agaricus blazei Murill-based Mushroom Extract

The results from this single-blinded randomized clinical trial shows significant improvement on symptoms, for both genders, in the AndoSanTM group, but no significant differences between the study groups. The results on fatigue, HRQoL, fecal calprotectin and blood samples were quite similar compared with placebo. The patients did not report any harms or unintended effects of AndoSanTM. CD patients with mild to moderate symptoms may have beneficiary effects of AndoSanTM as a safe supplement in addition to conventional medication.

read more

[#2016-03] Lion’s Mane Cheng, Jai-Hong et al High Molecular weight of polysaccharides from Hericium erinaceus against amyloiod beta-induced neurotoxic

Hericium erinaceus (HE) is a well-known mushroom in traditional Chinese food and medicine. HE extracts from the fruiting body and mycelia not only exhibit immunomodulatory, antimutagenic and antitumor activity but also have neuroprotective properties. Here, we purified HE polysaccharides (HEPS), composed of two high molecular weight polysaccharides (1.7 × 105 Da and 1.1 × 105 Da), and evaluated their protective effects on amyloid beta (Aβ)-induced neurotoxicity in rat pheochromocytoma PC12 cells.  Methods: HEPS were prepared and...

read more