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[#2015-03] Poria Cheng, Shujie et al. P...

Pachymic acid (PA) is a purified triterpene extracted from medicinal fungus Poria cocos. In this paper, we investigated the anticancer effect of PA on human chemotherapy resistant pancreatic cancer. PA triggered apoptosis in gemcitabine-resistant pancreatic cancer cells PANC-1 and MIA PaCa-2. Comparative gene expression array analysis demonstrated that endoplasmic reticulum (ER) stress was induced by PA through activation of heat shock response and unfolded protein response related genes. Induced ER stress was confirmed by increasing expression of XBP-1s, ATF4,...
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[#2014-08] Poria Tang, Jin et al. Charac...

Poria cocos F.A.Wolf is a Chinese traditional medicine used to treat chronic gastritis, edema, nephrosis, gastric atony, and acute gastroenteric catarrh. Polysaccharides are the main active component of P.cocos. We obtained polysaccharides PCP-1, PCP-2, and PCP-3 from the degradation of P. cocos polysaccha-rides (PCP) with different concentrations of H2O2 solution. Molecular weights were determined by high performance size exclusion chromatography. HPLC analysis of monosaccharide composition confirmed that PCP-1, PCP-2, and PCP-3 are heteropolysaccharides composed of...
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[#2013-16] Poria Cheng, Shujie et al. ...

Abstract. Poria cocos is a medicinal mushroom that is widely used in traditional Asian medicine. Here, we show that a characterized mixture of triterpenes extracted from P. cocos (PTE) and three purified triterpenes: pachymic acid (PA), dehydropachymic acid (DPA) and polyporenic acid C (PPAC) suppress the proliferation of the human pancreatic cancer cell lines Panc-1, MiaPaca-2, AsPc-1 and BxPc-3. Moreover, the most effective compound, PA, only slightly affects the proliferation of HPDE-6 normal pancreatic duct epithelial cells. The anti-proliferative effects of PTE on...
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BIORESEARCH UPDATE NEWS LETTER #1 Medici...

  Medicinal Mushrooms  For OPTIMUM HEALTH AND LONGEVITY  Ken Babal, C.N. We all know that vitamin and mineral supplements can augment diets by providing essential nutrients that ward off disease. Likewise, botanicals can help us stay well, and can be used medicinally. There is yet a third category that ranks high for cultivating optimum health and resistance to disease. This is the mushroom category. Mushrooms are members of the fungal family, sometimes referred to as the third kingdom. Being neither plant nor animal, they possess highly unique characteristics that...
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[#2011-10] Poria Li, Tzu-Hsuan et al. An...

Anti-Hyperglycemic Properties of Crude Extract and Triterpenes from Poria cocos Tzu-Hsuan Li,1,2 Chia-Chung Hou,1 Cicero Lee-Tian Chang,3 and Wen-Chin Yang1,2,4,5 1Agricultural Biotechnology Research Center, Academia Sinica Taipei 115, Taiwan 2Department and Institute of Pharmacology, National Yang-Ming University Taipei 112, Taiwan 3Department of Veterinary Medicine, National Chung Hsing University Taichung, Taiwan 4Institute of Zoology, National Taiwan University Taipei 10617, Taiwan 5Department of Life Sciences, National Chung Hsing University Taichung,...
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[#2010-17] Poria Ma, Chia-Yu et al. Immu...

Immunomodulatory Effect of the Polysaccharide-Rich Fraction from Sclerotium of Medicinal Mushroom Poria cocos F.A. Wolf (Aphyllophoromycetideae) on Balb/c Mice Chia-Yu Ma,1 Wan-Ching Chang,2 Hung-Min Chang,2 & James Swi-Bea Wu2,* 1Department of Food and Beverage Management, Technology and Science Institute of Northern Taiwan, Taipei City 112, Taiwan; 2Graduate Institute of Food Science and Technology, National Taiwan University, Taipei City 106, Taiwan   ABSTRACT: Dried sclerotia of medicinal mushroom Poria cocos F.A.Wolf were extracted with cold water. The...