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[#2016-09] Meshima Konno, Sensuke et al...

Abstract Severe side effects from chemotherapy or immunotherapy often limit their clinical utility in urothelial cell carcinoma of the bladder. To explore alternative therapies, we were particularly interested in one of medicinal mushrooms called Phellinus linteus (PL) with antitumor/anticancer activity. We investigated possible anticancer effects of three distinct extracts or fractions of PL using an urothelial cell carcinoma (UCC) model in vitro. Those fractions included PL-I (crude extract), PL-II (water-extracted), and PL-III (ethanol-extracted), which were tested for...
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[#2015-01] Meshima Konno, Sensuke et a...

Abstract Background: Although several therapeutic options are currently available for patients with various cancers, the outcomes are often disappointing and a more effective modality needs to be promptly established. We have been exploring an alternative approach using natural agents and two bioactive mushroom extracts isolated from Phellinus linteus (PL), namely PL-ES and PL-I-ES, were of our interest.  As anticancer effects of similar extracts have been reported in several cancers, we investigated whether PL-ES and PL-I-ES might have such anticancer activities on...
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[#2014-07] Meshima Chen, Yi-Shyan et al....

Abstract: Hispolon is one of the most important functional compounds that forms Phellinus linteus (Berkeley & Curtis) Teng. Hispolon has antioxidant, anti-inflammatory, antiproliferative and anticancer effects. In this study, we analyzed the functions of hispolon on melanogenesis and apoptosis in B16-F10 melanoma cells. The results demonstrated that hispolon is not an enzymatic inhibitor for tyrosinase; rather, it represses the expression of tyrosinase and the microphthalmia-associated transcription factor (MITF) to reduce the production of melanin in...
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BIORESEARCH UPDATE NEWS LETTER #1 Medici...

  Medicinal Mushrooms  For OPTIMUM HEALTH AND LONGEVITY  Ken Babal, C.N. We all know that vitamin and mineral supplements can augment diets by providing essential nutrients that ward off disease. Likewise, botanicals can help us stay well, and can be used medicinally. There is yet a third category that ranks high for cultivating optimum health and resistance to disease. This is the mushroom category. Mushrooms are members of the fungal family, sometimes referred to as the third kingdom. Being neither plant nor animal, they possess highly unique characteristics that...
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[#2011-09] Effects of Phellinus linteus...

Effects of Phellinus linteus Administration on Serotonin Synthesis in the Brain and Expression of Monocarboxylate Transporters in the Muscle during Exhaustive Exercise in Rats Jin-Hee SEO1 , Yun-Hee SUNG’, Ki-Jeong KIM’, Mal-Soon SHIN’, Eun-Kyu LEE1.2 and Chang-Ju KIM 1.*  1Department of Physiology, College of Medicine, Kyung Hee University, #1 Hoigi-dong, Dongdaemoon-gu, Seoul 130-701, Republic of Korea 2Department of Internal Medicine, Andong Medical Group, #574-2 Susang-dong, Andong, Kyungbuk 760-410, Republic of Korea Summary This study was...
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[#2010-16] Medicinal mushroom Phellinus ...

Medicinal mushroom Phellinus linteus ( Meshima ) as an alternative cancer therapy (Review) DANIEL SLIVA1‘2‘3 1Cancer Research Laboratory, Methodist Research Institute; 2Department of Medicine, and 3lndiana University Cancer Center, Indiana University School of Medicine, Indianapolis, IN, USA Abstract. Alternative cancer treatment with nutritional/dietary supplements containing a wide variety of herbal products is on the rise in Western countries. Recent epidemiological studies have suggested that mushrooms may prevent against different types of cancers....