[#2020-01] Maitake Konno, Sensuke et al....

This study shows that anticancer activity of BCNU is significantly potentiated with PDF in T24 cells. This is rather attributed to inactivated Gly-I and increased oxidative stress. Therefore, PDF appears to have a chemosensitizing effect capable of enhancing BCNU cytotoxicity, which may offer an alternative, improved therapeutic option for bladder cancer.

[#2019-03] Coriolus, Maitake Roca-Lema...

Colorectal cancer (CRC) is one of leading cause of mortality in western countries and novel treatment strategies are required. The medicinal application of mushrooms has been used in traditional medicine in many oriental countries. Polysaccharide-rich extracts obtained from certain medicinal mushroom species have shown antitumor effects in different experimental models. In the present study, we have developed polysaccharide-rich extracts from Trametes versicolor (TV) and Grifola frondosa (GF) fruit bodies. We aim to evaluate the anticancer effects of...

[#2018-09] Maitake Zhang, Michael et al....

Bladder cancer is the second common genitourinary malignancy next to prostate cancer in the United States.1 Nearly 82,000 new cases would be diagnosed and ~ 17,000 people may die this year (2018).1 Approximately 75% of all newly diagnosed cases will present nonmuscle invasive bladder cancer (NMIBC) including stage Ta, T1 and carcinoma in situ,2,3 while other 25% are muscle invasive bladder cancers (MIBCs) or metastatic cancers.3 The primary treatment for NMIBC is transurethral resection of bladder tumor (TURBT);4 however, NMIBC following TURBT has a high recurrence...

[#2018-06] Maitake Mao, Guang-Hua et al....

GP11 had been reported to have effectively anti-tumor activity by improving the immune function in our previous study. To avoid drawbacks of the 5-Fu, GP11 in combinationwith 5-Fuwas investigated in this study. The results demonstrated that such synergism displayed enhance the anti-tumor activity of 5-Fu. Additionally, a strength effectwas also observed in regulating immune function of GP11 and 5-Fu simultaneous administration, such as enhancing seruminterleukin-2 (IL-2) and tumor necrosis factor-alpha (TNF-α) secretion, and increasing immune organs weights....

[#2018-05] Maitake Huang, Jian et al. Gr...

Grifola frondosa polysaccharide (GFP) is the extract of Grifola frondosa. In this study, 50 male wistar rats were separated into S + C, S + T, LG + T, MG + T and HG + T groups to study the effect of GFP on the immune function of heavy load exercising rats. In S + T group, blood neutrophil number, neutrophil phagocytic index and bactericidal capacity decreased significantly, and adhesion function showed remarkable increase after 8 weeks excessive exercise. Low, medium and high doses of GFP were administered to different groups based on gavage. After gavaging GFP during...

[#2018-04] Maitake Li, Qian et al. Purif...

A novel bioactive polysaccharide, GFP-22, was isolated from the fruit bodies of Grifola frondosa by anion-exchange and gel filtration chromatography. Structure of GFP-22 was investigated using gas chromatography–mass spectrometry (GC–MS), methylation, nuclear magnetic resonance (NMR), high-performance size exclusion chromatography-multi-angle laser light scattering-refractive index detector (HPSEC-MALLS-RI) and atomic force microscopy (AFM) analysis. The backbone of GFP-22 is composed of 1,4-β-D-Glcp, 1,3-β-D-Glcp, 1,6-α-D-Glcp, 1,6-α-D-Galp, 1,4,6-α-D-Manp...