delete

BIORESEARCH UPDATE NEWS LETTER #10 Can M...

Immediate Release                      ~ A New Gene Study Suggests Strong Clinical Implications ~   January 20, 2014-  A research group of National Scientific and Technical Research Council in Argentina (CONICET) headed by Dr. Gabriela Balogh has announced that they have successfully identified genes that would be responsible for the tumor supression in human breast cancer cells (MCF-7) by a mushroom extract called Maitake D-Fraction. The results include that D-Fraction may even revert the malignancy of cancer cells by the modification of related...
delete

[#2013-13] Maitake Tsao, Yao-Wei et al. ...

Grifola frondosa, also known as maitake, is a culinary mushroom with immune-enhancing and antitumor effects. Numerous studies have investigated the activity of maitake polysaccharide extracts, but studies of maitake proteins are scarce. In this study, we purified and characterized a new G. frondosa protein, GFP, from maitake fruiting bodies. GFP is a nonglucan heterodimeric 83 kDa protein that consists of two 41 kDa subunits. GFP induced interferon-γ secretion by murine splenocytes and natural killer cells and activated the maturation of bone marrow-derived dendritic...
delete

[#2013-12] Maitake Su, Chun-Han et al In...

This study has demonstrated that the nonpolar fraction of GF possesses potent anti-a-glucosidase activity, and its inhibitory kinetics is competitive inhibition. It was as good as acarbose in inhibiting starch digestion in vitro. This study also suggests that oleic acid and linoleic acid could be the major active compounds of GF contributing to the potent anti-a-glucosidase activity
delete

[#2013-11] Maitake Lei, Hong et al. MT-...

The hypoglycemic effect of an α-glucan (designated here as MT-α-glucan) from the fruit body of the Maitake medicinal mushroom, Grifola frondosa, on a murine type 2 diabetes mellitus (T2DM) model was evaluated. Body weight and levels of fasting plasma glucose, glycosylated hemoglobin, triglycerides, cholesterol, free fatty acid, nitric oxide (NO), NO synthase, inducible NO synthase, and hepatic malondialdehyde content decreased significantly when MT-α-glucan was administered to T2DM mice. The content of serum insulin, hepatic glycogen, and reduced glutathione and the...
delete

[#2013-10] Alternative Therapeutic Appro...

Because of a dismal prognosis for advanced renal-cell carcinoma (RCC), an alternative therapeutic approach, using vitamin K3 (VK3) and D-fraction (DF) was investigated. VK3 is a synthetic VK derivative and DF is a bioactive mushroom extract, and they have been shown to have antitumor activity. We examined if the combination of VK3 and DF would exhibit the improved anticancer effect on RCC in vitro. Materials and Methods: Human RCC, ACHN cell line, were treated with varying concentrations of VK3, DF, or a combination of the two. Cell viability was assessed at 72 hours by...
delete

[#2013-03] Maitake, Eliana Noelia Alons...

It is already known that the Maitake (D-Fraction) mushroom is involved in stimulating the immune system and activating certain cells that attack cancer, including macrophages, T-cells, and natural killer cells. According to the U.S. National Cancer Institute, polysaccharide complexes present in Maitake mushrooms appear to have significant anticancer activity. However, the exact molecular mechanism of the Maitake antitumoral effect is still unclear. Previously, we have reported that Maitake (D-Fraction) induces apoptosis in breast cancer cells by activation of...