[#2010-02] Reduction of depression and a...

Reduction of depression and anxiety by 4 weeks Lion’s Mane ( Hericium erinaceus ) intake Mayumi Nagano¹, Kuniyoshi Shimizu2, Ryuichiro Kondo2, Chickako Hayashi3, Daigo Sato4, Katsuyuki Kitagawa4, and Koichiro Ohnuki3 1Department of Clinical Psychology, Kyoto Bunkyo University, Japan  2 Faculty of Agri­culture, Kyushu University, Japan  3 Kyushu-Eiyouhukushi University, Japan; and  4 Aso Biotech , Kawayo, Japan   ABSTRACT Hericium erinaceus, a well known edible mushroom, has numerous biological activities. Especial­ly hericenones and erinacines isolated...

[#2009-04] Improving Effects of the Mush...

Improving Effects of the Mushroom Yamabushitake (Hericium erinaceus) on Mild Cognitive Impairment: A Double-blind Placebo-controlled Clinical Trial Koichiro Mori1*, Satoshi Inatomi1, Kenzi Ouchi1, Yoshihito Azumi1 and Takashi Tuchida2 1Mushroom Laboratory, Hokuto Corporation, 800-8, Shimokomazawa, Nagano 2Isogo Central and Neurosurgical Hospital, , Yokohama,  Japan   A double-blind, parallel-group, placebo-controlled trial was performed on 50- to 80-year-old Japanese men and women diagnosed with mild cognitive impairment in order to examine the efficacy of oral...

[#2008-04] Effect of Culinary-Medicinal ...

Effect of Culinary-Medicinal Lion’s Mane Mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae), on Ethanol-Induced Gastric Ulcers in Rats Mahmood Ameen Abdulla,’,* Suzita Mohd Noor,’ Vikineswary Sabaratnam,2 Noorlidah Abdullah,2 Kah-Hui Wong,2 & Hapipah Mohd Ali3 ‘Department of Molecular Medicine, Faculty of Medicine, 2Institute of Biological Science, Faculty of Science, 3Department of Chemistry, Faculty of Science, University of Malaya ABSTRACT: The cytoprotective effect of Hericium erinaceus freeze-dried fruiting bodies was...

[#2008-03] Compounds for dementia from H...

Compounds for dementia from Hericium erinaceum.   Kawagishi, Hirokazu and Zhuang, Cun Abstract Our group has been conducting a search for com­pounds for dementia derived from medicinal mush­rooms since 1991. A series of benzyl alcohol deriva­tives (named hericenones C to H), as well as a series of diterpenoid derivatives (named erinacines A to I) were isolated from the mushroom Hericium erinaceum. These compounds significantly induced the synthesis of nerve growth factor (NGF) in vitro and in vivo. In a recent study, dilinoleoyl-phosphatidylethanolamine (DLPE) was...

[#2007-02] BIOACTIVE COMPOUNDS FROM MUSH...

BIOACTIVE COMPOUNDS FROM MUSHROOMS Hirokazu Kawagishi and Cun Zhuang   Anti-dementia Compounds We have been engaged in a study to search for nerve growth factor (NGF) synthesis-promoting compounds in medicinal mushrooms,  since 1991. We discovered a series of benzyl alcohol derivatives named as hericenones C — H (1 - 6), as well as a series of diterpenoid derivatives named as erinacines A — 1 (7 -15) from Hericium erinaceum, which evidently stimulate NGF production from mouse astroglial...

[#2006-01] Lion’s Mane Nagai, Kaor...

Dilinoleoyl-phosphatidylethanolamine from Hericium erinaceum protects against ER stress-dependent Neuronal cell death via protein kinase C pathway Kaoru Nagai a,*, Akiko Chibab, Toru Nishinoa, Takeo Kubotaa, Hirokazu Kawagishib,* aDepartment of Epigenetic Medicine, Interdisciplinary Graduate School ofMedicine and Engineering, University of Yamanashi, Yamanashi 409-3898, Japan bDepartment of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, Shizuoka 422-8529, Japan Abstract In many types of neurodegeneration, neuronal cell death is induced by...