[#2004-08] Safety of Maitake D-Fraction ...

Safety of Maitake D-Fraction in Healthy Patients Glauco, S(a), Jano, F(a), Paolo, G(a), Konno, S(b) a) Practicing Physicians in Italy b) New York Medical College Both in vivo and in vitro studies and limited clinical trials thus far support a potent immunostimulatory, anticancer or antitumor as well as apoptosis-inducing activity for D-fraction, which may have great potential for cancer treatment and prevention. However, information on the safety of D-fraction or actual positive or negative effects of D-fraction on healthy human subjects had yet been lacking or...

[#2004-07] Potential growth inhibitory e...

Potential growth inhibitory effect of maitake D-fraction on canine cancer cells Konno S. Department of Urology, New York Medical College The postulated anticancer effect of D-fraction, the bioactive extract of maitake mushroom, on three types (CF33, CF21, and CL-1) of canine cancer cells was evaluated. The effect of D-fraction on several human cancer cells was also investigated. The effect of other β-glucan products was likewise examined. D-fraction was highly effective on the canine cancer cells, either potently inhibiting cell growth or directly killing cells. Similar...

[#2002-18] Maitake Konno, Sensuke Maitak...

Introduction Despite the medicinal aspects of several mushrooms having been passed down through folklore in the Orient, the scientific study of these mushrooms to explore their biological properties has been initiated only within the past 20 years. A number of researchers have particularly focused their attention on one of these mushrooms called maitake {Grifola frondosa) mushroom. ”Maitake” (pronounced “my-tah-keh”) is an edible, tasty mushroom and literally means “dancing mushroom.” Characteristically, it is a giant mushroom that...

[#2002-05] Maitake: Finkelstein, Michael...

Chemosensitization of carmustine with maitake β-glucan on androgen-independent prostatic cancer cells: involvement of glyoxalase I Finkelstein MP, Aynehchi S, Samadi AA, Drinis S, Choudhury MS, Tazaki H, Konno S. Department of Urology, New York Medical College OBJECTIVE: To improve the poor efficacy (< 10%) of chemotherapy for patients with hormone-refractory prostate cancer, we investigated a possible cytotoxic effect of carmustine/β-glucan combination on prostatic cancer PC-3 cells, focusing on a glutathione-dependent detoxifying enzyme, glyoxalase I...

[#2000-05] Induction of apoptosis in hum...

Induction of apoptosis in human prostatic cancer cells with β-glucan (Maitake mushroom polysaccharide) Fullerton SA, Samadi AA, Tortorelis DG, Choudhury MS, Mallouh C, Tazaki H, Konno S. Department of Urology, New York Medical College PURPOSE: To explore more effective treatment for hormone-refractory prostate cancer, we investigated the potential antitumor effect of β-glucan, a polysaccharide of the Maitake mushroom, on prostatic cancer cells in vitro. MATERIALS AND METHODS: Human prostate cancer PC-3 cells were treated with various concentrations of the highly purified...

[#1997-02] Maitake D-Fraction: Healing a...

Maitake D-Fraction: Healing and Preventive Potential for Cancer Nanba, H Kobe Pharmaceutical University, Japan Author has been studying medicinal mushrooms for the last 15 years and has reported that of all mushrooms studied, Maitake Mushroom (Grifola frondosa) has the strongest activity in tumor growth inhibition both in administered orally and intraperitoneally. In this report, Maitake extract D-fraction was investigated to determine its effectiveness not only on the inhibition against tumors already growing, but also on the inhibition of formation of the secondary focus...