[#2013-12] Maitake Su, Chun-Han et al In...

This study has demonstrated that the nonpolar fraction of GF possesses potent anti-a-glucosidase activity, and its inhibitory kinetics is competitive inhibition. It was as good as acarbose in inhibiting starch digestion in vitro. This study also suggests that oleic acid and linoleic acid could be the major active compounds of GF contributing to the potent anti-a-glucosidase activity

[#2013-11] Maitake Lei, Hong et al. MT-...

The hypoglycemic effect of an α-glucan (designated here as MT-α-glucan) from the fruit body of the Maitake medicinal mushroom, Grifola frondosa, on a murine type 2 diabetes mellitus (T2DM) model was evaluated. Body weight and levels of fasting plasma glucose, glycosylated hemoglobin, triglycerides, cholesterol, free fatty acid, nitric oxide (NO), NO synthase, inducible NO synthase, and hepatic malondialdehyde content decreased significantly when MT-α-glucan was administered to T2DM mice. The content of serum insulin, hepatic glycogen, and reduced glutathione and the...

[#2013-10] Alternative Therapeutic Appro...

Because of a dismal prognosis for advanced renal-cell carcinoma (RCC), an alternative therapeutic approach, using vitamin K3 (VK3) and D-fraction (DF) was investigated. VK3 is a synthetic VK derivative and DF is a bioactive mushroom extract, and they have been shown to have antitumor activity. We examined if the combination of VK3 and DF would exhibit the improved anticancer effect on RCC in vitro. Materials and Methods: Human RCC, ACHN cell line, were treated with varying concentrations of VK3, DF, or a combination of the two. Cell viability was assessed at 72 hours by...

[#2013-03] Maitake, Eliana Noelia Alons...

It is already known that the Maitake (D-Fraction) mushroom is involved in stimulating the immune system and activating certain cells that attack cancer, including macrophages, T-cells, and natural killer cells. According to the U.S. National Cancer Institute, polysaccharide complexes present in Maitake mushrooms appear to have significant anticancer activity. However, the exact molecular mechanism of the Maitake antitumoral effect is still unclear. Previously, we have reported that Maitake (D-Fraction) induces apoptosis in breast cancer cells by activation of...

[#2013-02] Maitake Konno, Sensuke et al ...

The present study suggests that SXF may specifically target the insulin signal pathway, and, in particular, the IR and IRS-1 therein that trigger the subsequent signaling events. As a result, SXF could activate such an impaired signal pathway through high Glc or under a hyperglycemic milieu, thereby ultimately facilitating Glc uptake. This may then account for possible hypoglycemic action of SXF.

BIORESEARCH UPDATE NEWS LETTER #8 Patent...

April 4, 2013 – Japan   SX-fraction (called Grislin in Japan), a proprietary extract derived from Maitake Mushroom, has been patented in three countries.  Japan, the US and Canada, entitled, “A Glycoprotein with Anti-diabetic, Anti-hypertensive, Anti-obesity and Anti-hyperlipidemic effects.”  Its new patent against PCOS (Polycystic Ovary Syndrome) is now registered in the same three countries.  PCOS is a leading cause of infertility, affecting 5-10 % of women of reproductive age and believed to be closely associated with insulin resistance or...