[#1991-01] Hericenones C, D and E, stimulators of nerve growth factor (NGF)- synthesis, from the mushroom Hericium erinaceum, H. Kawagishi et al.

Hericenones C, D and E, stimulators of nerve growth factor (NGF)- synthesis, from the mushroom Hericium erinaceum

Hirokazu Kawagishi*, Motoharu Ando, Hideki Sakamoto, Satoshi Yoshida, Fumihiro Ojima, Yukio Ishiguro, Nobuo Ukai and Shoei Furukawa

Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University 836 Ohya, Shizuoka 422, Japan.

Research Institute, Kagome Co., Ltd., 17 Nishitomiyama, Nishinasuno, Tochigi 329-27, Japan

Department of Molecular Biology, Gifu Pharmaceutical University, 5-6-1 Mitahora-Higashi, Gifu 502, Japan

Abstract: Novel compounds, hericenones  C (3), D (4) and E (5) were isolated from the mushroom Hericium erinaceum ( lion’s mane ). These structures were determined by interpretation of the spectral data, and chemical and enzymatic reactions. These compounds have stimulating activity of the synthesis of nerve growth factor (NGF).