[#1995-08] Effects of Administration of Grifola frondosa on Glucose Tolerance and Glucosuria in Rats with Experimental Diabetes, H. Horio et al.

Effects of Administration of Grifola frondosa on Glucose Tolerance and Glucosuria in Rats with Experimental Diabetes

Horio, H(a), Ohtsuru, M(b)

a) Department of Nutrition, Faculty of Home Economics, Yamaguchi Women’s University, b) Department of Food and Nutrition, School of Human Life and Environmental Sciences, Mukogawa Women’s University

The effects of Maitake (Grifola frondosa) on blood glucose levels in rats with streptozotocin-induced diabetes were investigated. Diabetic rats were produced by injecting 80 mg/kg streptozotocin into 2-day-old neonates. From the age of 9 weeks, the rats were given Maitake as a dietary admixture at 20% food weight for 180 days. Diabetic rats showed obvious diabetic symptoms such as hyperglycemia, hyperphagia, polydipsia, polyuria, and glucosuria. The diabetic levels of blood glucose, water consumption, urine volume and glucosuria were significantly decreased in the rats fed Maitake. From these results, it may be considered that the bioactive substances present in Grifola frondosa ameliorate the symptoms of diabetes.