Structures of New Ceramides from the Fruit Bodies of Grifola frondosa Yasunori YAOITA, Takaaki ISHIZUKA, Rie KAKUDA, Koichi MACHIDA, and Masao KIKUCHI* ToKyo Pharmaceutical University, Japan. Four new phytosphingosine-type ceramides, (25,35,4R)-2-[(2'R)-2'-hydroxydocosanoylamino1-1,3,4-octadecanetriol (1), (2S,3S,4R)-2-[(2'R)-2'-hydroxytricosanoylamino]-1,3,4-octadecanetriol (2), (2S,3S,4R)-2-[(2'R)-2'- hydroxypentacosanoylamino]-1,3,4-octadecanetriol (3) and (2S,3S,4R)-2-[(2'R)-2'-hydroxyhexacosanoylamino]- 1,3,4-octadecanetriol (4), have...
read moreAngiotensin I-Converting Enzyme Inhibitory Peptides from Pepsin Digest of Maitake (Grifola frondosa) Ohtsuru, M(a), Horio, H(b), Masui, H(c) a) Department of Food Science and Nutrition, Mukogawa University, b) Department of Food Science and Nutrition, Nishikyushu University, c) Department of Dietary Life and Food Science, Mukogawa Women’s University Junior College Division Three peptides which inhibit angiotension I-converting enzyme were isolated from maitake (Grifola frondosa) water extract digested by pepsin. Among them,...
read moreEffects of Maitake (Grifola frondosa) glucan in HIV-infected Patients Nanba, H(a), Kodama, N(a), Schar, D(b), Turner, D(b) a) Department of Microbial Chemistry, Kobe Pharmaceutical University, b) Herbal Clinical Research, London The effects of MD-Fraction, a β-glucan extracted from Maitake mushroom (Grifola frondosa), on the health status of individuals suffering from HIV infection were evaluated in a long-term trial. The HIV status of the 35 respondents who participated in the study was followed by monitoring CD4+ cell counts, viral load...
read moreSuppression of D-galactosamine-induced liver injury by mushrooms in rats Lee EW, He P, Kawagishi H, Sugiyama K. Department of Applied Biochemistry, Faculty of Agriculture, Shizuoka University, Japan. Six species of edible mushroom were found to suppress D-galactosamine-induced enhancement of plasma alanine and aspartate aminotransferase activities when powdered mushrooms were added to the diet (5%) and fed to rats for 2 wk. Grifola frondosa ( maitake ) exhibited the most potent effect in a dose-dependent manner. A significant effect was...
read moreInduction of apoptosis in human prostatic cancer cells with β-glucan (Maitake mushroom polysaccharide) Fullerton SA, Samadi AA, Tortorelis DG, Choudhury MS, Mallouh C, Tazaki H, Konno S. Department of Urology, New York Medical College PURPOSE: To explore more effective treatment for hormone-refractory prostate cancer, we investigated the potential antitumor effect of β-glucan, a polysaccharide of the Maitake mushroom, on prostatic cancer cells in vitro. MATERIALS AND METHODS: Human prostate cancer PC-3 cells were treated with various...
read moreEffects of maitake (Grifola frondosa) polysaccharide on collagen-induced arthritis in mice Shigesue K, Kodama N, Nanba H. Department of Microbial Chemistry, Kobe Pharmaceutical University We recently reported the anti-hepatitis effect of a polysaccharide, designated as the D-fraction, extracted from maitake. Its effect includes immuno-regulating activities. We investigated the effect of the glucan in collagen-induced arthritis (CIA). The D-fraction was administered to CIA mice for 30 consecutive days. Arthritis development was observed from...
read moreActivities of Polysaccharides Obtained from Grifola frondosa on Insulin-dependent Diabetes Mellitus Induced by Streptozotocin in Mice Kurushima, H, Kodama, N, Nanba, H Department of Microbial Chemistry, Kobe Pharmaceutical University In an experiment with C57BL/6J model mice having insulin-dependent diabetes mellitus (IDDM) induced by streptozotocin, the glucans obtained from Maitake fruit body were found to suppress activation and proliferation of macrophages and consequently to inhibit the generation of nitric oxide (NO) and IL...
read moreTwo Novel Diterpenoids, Erinacines H and I from the Mycelia of Hericium erinaceum Eun Woo LEE, Kazue Surzuki, Satoshi HOSOKAWA, Masami Suzuki, Hiroyuki SUGANUMA, Takahiro INAKUMA, Jingxuan Li, Mayumi OHNISHI-KAMEYAMA, Tadahiro NAGATA, Shoei FURUKAWA, and Hirokazu KAwAcistn Novel diterpenoids, erinacines H (1) and I (3), were isolated from the cultured mycelia of Lion’s Mane mushroom (Hericium erinaceum). The structures of the compounds were determined by interpretation of the spectral data. Erinacine H showed stimulating...
read morePharmacological Functions of Chinese Medicinal Fungus Cordyceps sinensis and Related Species SHENG-YUAN WANG1,2 AND MING-SHI SHIAO1* 1. Department of Medical Research and Education, Veterans General Hospital-Taipei, Taipei, Taiwan 2. Institute of Traditional Medicine, National Yang-Ming University, Taipei, Taiwan ABSTRACT Cordyceps sinensis, an entomogenous fungus used in traditional Chinese medicine, exhibits very broad biological and pharmacological actions in hepatic, renal, cardiovascular, and immunologic systems as well as...
read moreActivity of Edible Mushrooms Against the Growth of Human T4 Leukemic Cancer Cells, HeLa Cervical Cancer Cells and Plasmodium falciparum Lovy, A(a), Knowles, B(b), Labbe, R, Nolan(c), L(b) a) Institute of Biological Chemistry, Washington State University, b) Department of Environmental Health Sciences, University of Massachusetts, c) Food Science Department, University of Massachusetts Several edible Hymenomycete mushroom species have been screened as possible inhibitors of human T4 leukemic cancer cells, HeLa cervical cancer cells,...
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