Erinacines A, B and C, strong stimulators of nerve growth factor (NGF)-synthesis, from the mycelia of Hericium erinaceum. Hirokazu Kawagishi*, Atsushi Shimada, Ryoko Shiraia, Kenji Okamotob, Fumihiro Ojimab, Hideki Sakamotob, Yukio Ishiguro, and Shoei Furukawa Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, 836 Ohya, Shizuoka 422, Japan. Research Institute, Kagome Co., Ltd., 17 Nishitomiyama, Nishinasuno-cho, Tochigi 329-27, Japan. cDepartment of Molecular Biology, Gifu Pharmaceutical University, 5-6-1...
read moreTHE REVISED HASEGAWA’S DEMENTIA SCALE(HDS-R) — EVALUATION OF ITS USEFULNESS AS A SCREENING TEST FOR DEMENTIA YUKIMICHI IMAI & KAZUO HASEGAWA Summary Revised Hasegawa’s dementia scale (HDS-R), consisting of 9 simple questions with a maximum score of 30, was examined in its usefulness for screening age-associated dementia in a total of 157 subjects: 95 demented patients and 62 non-demented persons. The two groups were age-matched. Cronbach’s coefficient alpha was as high as 0.90 in HDS-R. In addition, the coefficient...
read moreβ-Glucans Inhibitory Effect of Beta-Glucans on Zymosan-Mediated Hydrogen Peroxide Production by Murine Peritoneal Macrophages in Vitro Adachi, Y, Ohno, N, Yadomae, T Laboratory of Immunopharmacology of Microbial Products, Tokyo College of Pharmacy Effects of the pretreatment of murine peritoneal macrophages with several polysaccharides on the production of H2O2 induced with unopsonized zymosan were examined. Pretreatment with most of (1->3)-β-D-glucans for 6h at 37deg C inhibited the zymosan-mediated H2O2 production by macrophages....
read moreAnti-Hypertensive Effect by the King of Mushrooms Nanba, H Kobe Women’s College of Pharmacy The fungi which belong to Basidiomycetes have been used as herbal medicines for a long time. It has been found that shiitake (Lentinus edodes) and mannentake or reishi (Ganoderma lucidum) are effective against essential hypertension. The author was quite curious about the hypotensive action of Maitake (Grifola frondosa), another mushrooom belonging to basidiomycetes. In fact, the finding of this activity was a result of studying the antitumor...
read morePurification of a copper binding peptide from the mushroom Grifola frondosa and its effect on copper absorption Iwao Shimaoka,* Junko Kodama,* Kohsuke Nishino,t and Yoshinori Itokawa* *Department of Hygiene, Faculty of Medicine, Kyoto University; and tDepartment of Home Economics, Dohshisha Women’s College, Kyoto, Japan The present studies were undertaken to investigate the effect of a copper binding peptide on copper bioavailability. This peptide was extracted from the fruit bodies of the mushroom, Grifola frondosa ( maitake ), and...
read moreApplication of limulus test (G pathway) for the detection of different conformers of (1->3)-β-D-glucans Nagi N, Ohno N, Adachi Y, Aketagawa J, Tamura H, Shibata Y, Tanaka S, Yadomae T. Laboratory of Immunopharmacology of Microbial Products, Tokyo College of Pharmacy The reactivity of factor G mediated coagulation pathway in limulus amebocyte lysate which is triggered by (1->3)-β-D-glucans is thought to depend on the structure of the glucans, especially on the ultrastructure: triple helix, single helix and random coil. We used Sonifilan...
read moreCHROMANS, HERICENONES F, G AND H FROM THE MUSHROOM HERICIUM ERINACEUM HIROKAZU KAWAGISHI1,* MOTOHARU ANDO, KAYOKO SHINBA, HIDEKI SAKAMOTO, SATOSHI YOSHIDA, FUMIHIRO OJIMA, YUKIO ISHIGURO, NOBUO UKAI and SHOEI FURUKAWA: Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, 836 Ohya, Shizuoka 422, Japan; Research Institute, Kagome Co., Ltd, 17 Nishitomiyama, Nishinasuno, Tochigi 329-27, Japan; Department of Molecular Biology, Gifu Pharmaceutical University, 5-6-1 Mitahora-Higashi, Gifu 502,...
read moreEffect of Pachyman, a Main Component of Poria Cocos Wolf on Original-Type Anti-GBM Nephritis in Rats and Its Mechanisms Tomohisa Hattori, Kazumi Hayashi, Toshiyuki Nagao, Kazuya Furuta, Mikio Ito and Yoshio Suzuki Department of Pharmacology, Faculty of Pharmacy, Meijo University, Tenpaku-ku, Nagoya 468, Japan ABSTRACT—The antinephritic effect of pachyman on original-type anti-GBM nephritis in rats was investigated. Pachyman was given to original-type anti-GBM nephritic rats for 10 days from the day of anti-GBM serum injection. Pachyman...
read moreChemical Structure of Water-Soluble Alpha-Glucan in the Fruit Body of Grifola Frondosa Wei, B, Wu, Y, Okumura, N, Yamaguchi, R, Ueno, Y, Kato, K Department of Food Science, Gifu University Alpha-glucan composed of only D-glucose was extracted with boiling water from the fruit body of Grifola frondosa ( maitake ) and purified through the columns of DEAE-cellulose (borate form) and Sepharose CL-4B. The polysaccharide was found to be a glycogen-type from the results of methylation study and enzymic hydrolysis. About 1.3 ~106 of weight-average...
read morePreparation and Biological Activities of Sulfated Derivatives of (1-3)-β-D-Glucans Tatsuya SUZUKI, Naohito OHNO, Yoshiyuki ADACHI,* Alicia Fernandez CIRELLI, Javiar A. COVIAN,** and Toshiro YADOMAE* Tokyo College of Pharmacy, * 1432-1 Horinouchi, Hachioji, Tokyo, 192-03, Japan and Universidad de Buenos Aires, ** Pabellon II, Ciudad Universitaria, 1428 Buenos Aires, Argentina Sulfated derivatives of (1–>3)β-D-glucans with different degree of branching (DB) i.e., curdlan (linear, DB 0), grifolan (from maitake ) (6-0-substituted by...
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