Royal Agaricus Mushroom (Agaricus blazei Murill)

Royal Agaricus Mushroom (Agaricus blazei Murill)

Gift from God. For your strong immune system.

Originating from the mountain region of Piedade, Brazil, Royal Agaricus Mushroom (Agaricus blazei Murill) has been prized in Brazil as a panacea being called “Cogmelo de Deus,” Mushroom of God. It attracted scientists’ attention when they found much lower occurrence of adult diseases in this region. Then studies have been done in Japan in 1980s and 90s, which demonstrated various medicinal properties of Agaricus, including enhancement of immune system, suppression of tumor, reduction of elevated blood glucose, cholesterol and blood pressure. Agaricus became very popular as a cancer aid in Japan in late 1990s.

Bioactive constituents:
β-glucan, Heteroglucan, β-glucan protein complex, RNA-protein complex, Steroids

Bioactivities:
• Anti-tumor: Enhances immune functions / Activates macrophage, T-cell and NK-cell / Increases TNF-α production / Induces cancer cell apoptosis / Cytotoxicity
• Anti-hyperlipidemia: Lowers total cholesterol and LDL-cholesterol / Increases HDL-cholesterol / Prevents arteriosclerosis
• Anti-hepatitis: Lowers GOT (AST), GPT (ALT), and gamma-GTP / Improves liver functions
• Anti-allergy: Modulates immune system
• Anti-aging: Eliminates free radicals / Prevents the formation of peroxide lipids / Improves age-related disorders

References:
(1) H. Kawagishi et al, Phytochemistry, 27(9):2777 (1988)
(2) H. Kawagishi et al, Carbohydrate Research, 186:267 (1989)
(3) T. Mizuno et al, Agric. Biol. Chem., 54(11):2889 (1990)
(4) T. Mizuno et al, Agric. Biol. Chem., 54(11):2897 (1990)
(5) H. Kawagishi et al, Carbohydrate Polymers, 12:393 (1990)
(6) K. Sugiyama et al, Nippon Eiyo Shokuryo Gakkaishi (Japanese), 45(3): 265 (1992)
(7) H. Itoh et al, Japanese Journal of Pharmacology, Oct., 662 (1994)
(8) T. Mizuno, Food Reviews International, 11(1):167 (1995)
(9) H. Ito et al. Anticancer Research, Jan.-Feb., 17(1A):277 (1997)
(10) Y. Fujimiya et al, Cancer Immunol Immunother, 46:147 (1998)