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[#2014-02] Lion’s Mane Inanaga, Ka...

Introduction Nerve growth factor (NGF) is considered as a very promising candidate in the treatment of Alzheimer’s disease [1]. However, NGF is a protein that becomes inactive after oral administration. A breakthrough in treatment occurred with the discovery of a class of compounds derived from the Lion’s Mane mushroom (Yamabush­itake, Hericium erinaceum), which stimulate the production of NGF [2,3]. Bioactive substances in H. erinaceum including hericenones, have the potential to repair neurological damage, improve brain function, and possibly prevent and treat...
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[#2014-01] Lion’s Mane Inanaga, Ka...

1.Introduction Hericium erinaceum (HE; “Yamabushitake” in Japanese) is an edible mushroom that was named after the pom-poms worn by traditional warrior monks or the Yamabushi. HE has numerous multifunctional biological activities such as suppressing endo­plasmic reticulum stress, antioxidant activities, and stimulating nerve growth factor (NGF) synthesis. Several compounds extracted from HE exhibit neuro-protective activity in the brain [1234]. Our group previously reported 3 cases of mild neurocognitive disorders resulting from neuromedical treatments [5], which were...
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[#2013-15] Lion’s Mane Khan, Asa...

Mushrooms are considered as nutritionally functional foods and source of physiologically beneficial medicines.  Hericium erinaceus, also known as Lion’s Mane Mushroom or Hedgehog Mushroom, is an edible fungus, which has a long history of usage in traditional Chinese medicine. This mushroom is rich in some physiologically important components, especially β-glucan polysaccharides, which are responsible for anti-cancer, immuno-modulating, hypolipidemic, antioxidant and neuro-protective activities of this mushroom. H. erinaceus has also been reported to have...
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[#2013-09] Lion’s Mane Bin Liang ...

Hericium erinaceus, as a commonly used medicine or food, has attracted much attention due to its health effects when used as a home remedy for some diseases. The aim of this work was to investigate the hypoglycemic and hypolipidemic effects of aqueous extract of Hericium erinaceus (AEHE) in streptozotocin (STZ)-induced diabetic rats. Methods: Diabetes was induced in Wistar rats by the administration of STZ (55 mg/kg BW.) intraperitoneally. AEHE (100 and 200 mg/kg BW.) was administered for a period of 28 days. The effects of AEHE on glucose, insulin, and lipid files in...
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[#2013-04] Lion’s Mane Xiaodong S...

Although the medicinal mushroom Hericium erinaceus is used extensively in traditional Chinese medicine to treat chronic superficial gastritis, the underlining pharmaceutical mechanism is yet to be fully understood. In this study, minimum inhibitory concentration (MIC) values of extracts prepared from the fruiting bodies of 14 mushroom species (H. erinaceus, Ganoderma lucidum, Cordyceps militaris, Pleurotus eryngii, P. ostreatus, Agrocybe aegerita, Lentinus edodes, Agaricus brasiliensis, A. bisporus, Coprinus comatus, Grifola frondosa, Phellinus igniarius, Flammulina...
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BIORESEARCH UPDATE NEWSLETTER #7 Patent ...

April 3, 2013 Amycenone®, a proprietary extract developed from a mushroom called Lion’s Mane (Hericium erinaceus), has been awarded a patent in Japan.  Its patent in the U.S. is pending. Amyloban®3399, a dietary supplement containing Amycenone® as an active ingredient, has been widely used and a number of clinical cases have also been reported for its role in certain conditions such as benign or mild dementia, snoring, sleep apnea, low quality of sleeping, juvenile apathy syndrome and schizophrenia.  Presentations on its clinical and laboratory studies have been...