[#2014-10] Lion’s Mane Inanaga, Ka...

Hericium erinaceum (HE) is a unique mushroom for its cognitive function improving actions. HE is known as Yamabushitake in Japanese and Lion’s Mane in English.  Since the early 1990s, Kawagishi and his colleagues have been investigating the role of the compounds derived from HE in the treatment of dementia (Kawagishi et al., 1991; Kawagishi et al., 1992; Kawagishi et al., 2004; Kawagishi et al., 2008). Bioactive substances in HE have the potential to stimulate the production of NGF, repair neuronal damage and improve brain function if the substances in HE are...

[#2014-03] Lion’s Mane Rahman, MA ...

Oxidation of low-density lipoprotein (LDL) has been strongly suggested as the key factor in the pathogenesis of atherosclerosis. Mushrooms have been implicated in having preventive effects against chronic diseases due especially to their antioxidant properties. In this study, in vitro inhibitory effect of Hericium erinaceus on LDL oxidation and the activity of the cholesterol biosynthetic key enzyme, 3-hydroxy-3-methyl glutaryl coenzyme A (HMG Co-A) reductase, was evaluated using five liquid-liquid solvent fractions consisting of methanol : dichloromethane (M : DCM),...

[#2014-02] Lion’s Mane Inanaga, Ka...

Introduction Nerve growth factor (NGF) is considered as a very promising candidate in the treatment of Alzheimer’s disease [1]. However, NGF is a protein that becomes inactive after oral administration. A breakthrough in treatment occurred with the discovery of a class of compounds derived from the Lion’s Mane mushroom (Yamabush­itake, Hericium erinaceum), which stimulate the production of NGF [2,3]. Bioactive substances in H. erinaceum including hericenones, have the potential to repair neurological damage, improve brain function, and possibly prevent and treat...

[#2014-01] Lion’s Mane Inanaga, Ka...

1.Introduction Hericium erinaceum (HE; “Yamabushitake” in Japanese) is an edible mushroom that was named after the pom-poms worn by traditional warrior monks or the Yamabushi. HE has numerous multifunctional biological activities such as suppressing endo­plasmic reticulum stress, antioxidant activities, and stimulating nerve growth factor (NGF) synthesis. Several compounds extracted from HE exhibit neuro-protective activity in the brain [1234]. Our group previously reported 3 cases of mild neurocognitive disorders resulting from neuromedical treatments [5], which were...

[#2013-23] Lion’s Mane Wong, Jing ...

Hericium erinaceus is a famous tonic in oriental medicine. The gastroprotective effects of aqueous extract of H. erinaceus against ethanol-induced ulcers in Sprague Dawley rats were investigated. The possible involvements of lipid peroxidation, superoxide dismutase, and catalase were also investigated. Acute toxicity study was performed.The effects of aqueous extract of H. erinaceus on the ulcer areas, ulcer inhibition, gastric wall mucus, gross and histological gastric lesions, antioxidant levels, and malondialdehyde (MDA) contents were evaluated in ethanol-induced...

[#2013-15] Lion’s Mane Khan, Asa...

Mushrooms are considered as nutritionally functional foods and source of physiologically beneficial medicines.  Hericium erinaceus, also known as Lion’s Mane Mushroom or Hedgehog Mushroom, is an edible fungus, which has a long history of usage in traditional Chinese medicine. This mushroom is rich in some physiologically important components, especially β-glucan polysaccharides, which are responsible for anti-cancer, immuno-modulating, hypolipidemic, antioxidant and neuro-protective activities of this mushroom. H. erinaceus has also been reported to have...