[#2008-03] Compounds for dementia from H...

Compounds for dementia from Hericium erinaceum.   Kawagishi, Hirokazu and Zhuang, Cun Abstract Our group has been conducting a search for com­pounds for dementia derived from medicinal mush­rooms since 1991. A series of benzyl alcohol deriva­tives (named hericenones C to H), as well as a series of diterpenoid derivatives (named erinacines A to I) were isolated from the mushroom Hericium erinaceum. These compounds significantly induced the synthesis of nerve growth factor (NGF) in vitro and in vivo. In a recent study, dilinoleoyl-phosphatidylethanolamine (DLPE) was...

[#2007-02] BIOACTIVE COMPOUNDS FROM MUSH...

BIOACTIVE COMPOUNDS FROM MUSHROOMS Hirokazu Kawagishi and Cun Zhuang   Anti-dementia Compounds We have been engaged in a study to search for nerve growth factor (NGF) synthesis-promoting compounds in medicinal mushrooms,  since 1991. We discovered a series of benzyl alcohol derivatives named as hericenones C — H (1 - 6), as well as a series of diterpenoid derivatives named as erinacines A — 1 (7 -15) from Hericium erinaceum, which evidently stimulate NGF production from mouse astroglial...

[#2006-01] Lion’s Mane Nagai, Kaor...

Dilinoleoyl-phosphatidylethanolamine from Hericium erinaceum protects against ER stress-dependent Neuronal cell death via protein kinase C pathway Kaoru Nagai a,*, Akiko Chibab, Toru Nishinoa, Takeo Kubotaa, Hirokazu Kawagishib,* aDepartment of Epigenetic Medicine, Interdisciplinary Graduate School ofMedicine and Engineering, University of Yamanashi, Yamanashi 409-3898, Japan bDepartment of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, Shizuoka 422-8529, Japan Abstract In many types of neurodegeneration, neuronal cell death is induced by...

[#2005-01] Erinacine A increases catecho...

Erinacine A increases catecholamine and nerve growth factor content in the central nervous system of rats Mari Shimbo, Hirokazu Kawagishi, Hidehiko Yokogoshi Abstract Nerve growth factor (NGF) is an essential protein for supporting growth and maintenance of peripheral sympathetic neurons. A novel diterpenoid erinacine, isolated from the cultured mycelia of Hericium erinacium ( lion’s mane ), is known to have a potent stimulating effect on NGF synthesis. The effects of erinacine and related compounds in the brain in vivo are not known. In this study, we examined the...

[#2004-05] The Anti-Dementia Effect of L...

The Anti-Dementia Effect of Lion’s Mane Mushroom(Hericium erinaceum) and Its Clinical Application by Hirokazu Kawagishi, Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University Introduction Medicinal Mushrooms have become a hot item in the mass media in the last few years but the information being disseminated about them is not always scientifically accurate. Most of the studies on the efficacy of medicinal mushrooms that are available to the public are based on animal studies (usually in mice) or cultured cells. In these cases, the...

[#2002-02] The Inducer of the Synthesis ...

The Inducer of the Synthesis of Nerve Growth Factor From Lion’s Mane (Hericium erinaceus) Hirokazu Kawagishi, Ph.D., Shoei Furukawa, Ph.D., Cun Zhuang, Ph.D., and Rika Yunoki Abstract Nerve growth factor (NGF) is closely related to Alzheimer’s dementia, and studies have suggested that the disease may be pre­vented or its symptoms may be improved when NGF is given into the brain directly. However, since NGF is a protein it usually can­not pass through the blood-brain barrier. Recently, researchers have targeted on the substances that could pass through the...