[#1987-08] Antitumor Activities of Edible Mushrooms by Oral Administration, K. Mori et al.

Antitumor Activities of Edible Mushrooms by Oral Administration

Mori, K (a), Toyomasu, H (a), Nanba, H (b), Kuroda, H (b)

a) The Mushroom Research Institute of Japan, b) Kobe Women’s College of Pharmacy

Antitumor activities of edible mushrooms were investigated by breeding mice with the feed containing 10-30% (w/w) powdered fruit bodies. In allogeneic tumor systems (Sarcoma 180 in ICR mice), the tumor growth was suppressed to 40-50% by oral administration of edible mushrooms. While in syngeneic systems (B-16 melanoma or Lewis Lung carcinoma in C57BL/6, Meth-A fibrosarcoma in Balb/C), the feed containing Lentinus edodes (Shiitake) did not suppress the growth of all tumors, but the breeding with Grifola frondosa ( Maitake ) elongated the lifetime of mice to 145% in the case of Meth-A fibrosarcoma in Balb/C.