Effects of a water-soluble extract of maitake mushroom on circulating glucose/insulin concentrations in KK mice Manohar V, Talpur NA, Echard BW, Lieberman S, Preuss HG. Department of Physiology, Georgetown University Medical Center AIM: We examined benefits of a water-soluble extract of maitake mushroom designated as Fraction X (FXM) on the glucose/insulin metabolism of insulin-resistant KK mice, and compared the results of FXM with those of a sulphonylurea, Glipizide. DESIGN: In several acute studies, insulin-resistant KK mice were gavaged...
read moreInteractions of Lipid Metabolism and Intestinal Physiology with Tremella fuciformis Berk Edible Mushroom in Rats Fed a High-Cholesterol Diet with or without Nebacitin HSING-HSIEN CHENG,WEN-CHI HOU, AND MEI-LING LU Male adult Wistar rats were randomly divided into six groups in a 2 x 3 factorial design and fed diets containing different levels of Tremella fuciformis Berk (TFB) dietary fiber (0, 5, or 10%) and 1 g of cholesterol/100 g of diet with or without 0.7% Nebacitin for 4 weeks. TFB contained 6.2% soluble dietary fiber and 57.3% insoluble...
read moreThe Immunomodulating Eifects of Ganoderma lucidum (Curt.: Fr.) P. Karst. (Ling Zhi, Reishi Mushroom) (Aphyllophoromycetideae) Shufeng Zhou and Yihuai Gao ABSTRACT: This review highlights the recent research progress in the study of immunomodulating effects of Ganoderma lucidum (Curt.: Fr.) P. Karst. (reishi mushroom), which belongs to the higher Basidiomycetes. Several major substances with potent immunomodulating action have been isolated. These include polysaccharides (in particular β-D-glucans), proteins, and triterpenoids. The major...
read moreEffects of Total Triterpenoids Extract from Ganoderma lucidum (Curt.: Fr.) P. Karst. (Reishi Mushroom) on Experimental Liver Injury Models Induced by Carbon Tetrachloride or D-Galactosamine in Mice Ming-Yu Wang,’ Qiang Liu,’ Qing-Ming Che,2 and Zhi-Bin Lin’ ‘Department of Pharmacology, School of Basic Medical Sciences; and 2Department of Traditional Chinese Medicine Drugs, College of Pharmacy, People’s Republic of China ABSTRACT: The effect of total triterpenoids extract isolated from Reishi, Ganoderma...
read moreA Phase I/II Study of a Ganoderma lucidum (Curt .: Fr.) P. Karst. (Ling Zhi, Reishi Mushroom) Extract in Patients with Chronic Hepatitis B Yihuai Gao,’ Shufeng Zhou,2,* Guoliang Chen,3 Xihu Dai,4 Jingxian Ye,5 and He Gao’ 1 New Zealand Institute of Natural Medicines, Auckland, New Zealand; 2 Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore 3Shanghai Academy of Agricultural Sciences, Shanghai, China; 4Fuzhou General Hospital of Nanjing Military Region of the Peoples’ Liberation Army,...
read moreDehydrotrametenolic Acid Induces Preadipocyte Differentiation and Sensitizes Animal Models of Noninsulin-Dependent Diabetes Mellitus to Insulin Mayumi Sato, Takaaki Tai, Yoshiki Nunoura, Yukiko Yajima, Seiichi Kawashima and Keiji Tanaka We recently discovered that the triterpene acid compound dehydrotrametenolic acid promotes adipocyte differentiation in vitro and acts as an insulin sensitizer in vivo. This natural product has been isolated from dried sclerotia of Poria cocos WOLF (Polyporaceae), a well-known traditional Chinese medicinal...
read moreCyclooxygenase inhibitory and antioxidant compounds from the mycelia of the edible mushroom Maitake ( Grifola frondosa ) Zhang Y, Mills GL, Nair MG. Bioactive Natural Products Laboratory, Department of Horticulture and National Food Safety and Toxicology Center, Biosystems Engineering, Michigan State University The bioassay-guided isolation and purification of the hexane extract of the cultured mycelia of Maitake ( Grifola frondosa ) led to the characterization of a fatty acid fraction and three compounds, ergosterol (1),...
read moreMolecular cloning and characterization of a cDNA encoding cellobiose dehydrogenase from the wood-rotting fungus Grifola frondosa Makoto Yoshida, Tsuyoshi Ohira, Kiyohiko Igarashi, Hiromichi Nagasawa, Masahiro Samejima GraduateSchoolof Agricultural and Life Sciences, The University of Tokyo Abstract Cloning of a cDNA encoding cellobiose dehydrogenase (CDH) from the wood-rotting fungus Grifola frondosa, which produces the edible maitake mushroom, was performed using reverse transcription-polymerase chain reaction (RT-PCR) and rapid...
read moreEffects of Maitake mushroom fractions on blood pressure of Zucker fatty rats Talpur N, Echard B, Dadgar A, Aggarwal S, Zhuang C, Bagchi D, Preuss HG. Department of Physiology, Medicine and Pathology, Georgetown University Medical Center A link exists between insulin resistance and many chronic disorders of aging including advancing-age. A safer means to prevent or, at least, slow the erosion of insulin sensitivity would provide a novel approach to better health. We compared the ability of a specific extract labeled fraction SX, as well as...
read moreAntihypertensive and metabolic effects of whole Maitake mushroom powder and its fractions in two rat strains Talpur NA, Echard BW, Fan AY, Jaffari O, Bagchi D, Preuss HG. Department of Physiology and Biophysics, Georgetown University Medical Center Maitake mushroom has been reported to favorably influence hypertension and diabetes mellitus. The purpose of this study was to compare the effects of whole Maitake mushroom powder and two extracts designated as ether soluble (ES) and water soluble (WS) on Zucker fatty rats (ZFR), a model of insulin...
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