REFERENCES
[#2002-07] Can Maitake MD-Fraction Aid Cancer Patients?, Noriko Kodama et al.
Can Maitake MD-Fraction Aid Cancer Patients? Noriko Kodama, PhD, Kiyoshi Komuta, MD, PhD, and Hiroaki Nanba, PhD Abstract Maitake mushroom (Grifola frondosa) MD-fraction containing beta-1,6 glucan with beta-1,3 branched chains has previously exhibited strong anticancer activity by increasing immune-competent cell activity.1,2 In this nonrandom case series, a combination of MD-fraction and whole maitake powder was investigated to determine its effectiveness for 22- to 57-year-old cancer patients in stages II-IV. Cancer regression or...
read more[#2002-06] Effects of D-Fraction, a polysaccharide from Grifola frondosa on tumor growth involve activation of NK cells, Noriko Kodama et al.
Effects of D-Fraction, a polysaccharide from Grifola frondosa on tumor growth involve activation of NK cells Kodama N, Komuta K, Sakai N, Nanba H. Department of Microbial Chemistry, Kobe Pharmaceutical University Natural killer (NK) cells are directly cytotoxic for tumor cells and play a primary role in regulating immune responses. We monitored levels of NK cell cytotoxic activity in cancer patients receiving D-Fraction extracted from maitake mushrooms (Grifola frondosa). Elevated levels of cytotoxic activity were maintained for one year. To...
read more[#2002-05] Maitake: Finkelstein, Michael P. et al.
Chemosensitization of carmustine with maitake β-glucan on androgen-independent prostatic cancer cells: involvement of glyoxalase I Finkelstein MP, Aynehchi S, Samadi AA, Drinis S, Choudhury MS, Tazaki H, Konno S. Department of Urology, New York Medical College OBJECTIVE: To improve the poor efficacy (< 10%) of chemotherapy for patients with hormone-refractory prostate cancer, we investigated a possible cytotoxic effect of carmustine/β-glucan combination on prostatic cancer PC-3 cells, focusing on a glutathione-dependent detoxifying...
read more[#2002-04] Maitake: Inoue, Atsuyuki et al ‘D-Fraction Immunity and Anti-tumor’
Effect of maitake (Grifola frondosa) D-fraction on the control of the T lymph node Th-1/Th-2 proportion Inoue A, Kodama N, Nanba H. Department of Microbial Chemistry, Kobe Pharmaceutical University We have already reported that the D-Fraction, a β-glucan extracted from the fruiting body of the maitake mushroom (Grifola frondosa), activates cellular immunity and expresses anti-tumor effects. In this study we investigated the anti-tumor functions of D-Fraction in relation to its control of the balance between T lymphocyte subsets Th-1 and Th-2....
read more[#2002-03] A polysaccharide, extract from Grifola frondosa, induces Th-1 dominant responses in carcinoma-bearing BALB/c mice, Noriko Kodama et al.
A polysaccharide, extract from Grifola frondosa, induces Th-1 dominant responses in carcinoma-bearing BALB/c mice Kodama N, Harada N, Nanba H. Department of Microbial Chemistry, Kobe Pharmaceutical University A polysaccharide, designated as the D-fraction, extracted from maitake (Grifola frondosa), was reported to have anti-tumor effects by activating macrophages and T cells in C3H/HeN mice in which a Th-1 dominant response was established. In this study using BALB/c mice in which a Th-2 response is genetically dominant, D-fraction reduced the...
read more[#2002-02] The Inducer of the Synthesis of Nerve Growth Factor From Lion’s Mane (Hericium erinaceus), Hirokazu Kawagishi et al.
The Inducer of the Synthesis of Nerve Growth Factor From Lion’s Mane (Hericium erinaceus) Hirokazu Kawagishi, Ph.D., Shoei Furukawa, Ph.D., Cun Zhuang, Ph.D., and Rika Yunoki Abstract Nerve growth factor (NGF) is closely related to Alzheimer’s dementia, and studies have suggested that the disease may be prevented or its symptoms may be improved when NGF is given into the brain directly. However, since NGF is a protein it usually cannot pass through the blood-brain barrier. Recently, researchers have targeted on the...
read more[#2002-01] Royal Agaricus, Mizuno, Takashi Medicinal Properties and Clinical Effects of Culinary-Medicinal Mushroom Agaricus Murrill (Agaricomycetideae) (Review)
Medicinal Properties and Clinical Effects of Culinary-Medicinal Mushroom Agaricus Murrill (Agaricomycetideae) (Review) Takashi Mizuno Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, Japan ABSTRACT: Agaricus Hazel Murrill (“Kawariharatake” in Japan, “Cogmelo de Deus” in Brazil) was first discovered in Florida, USA, in 1944. Its main natural habitat is the mountainous district of Piedade in Sao Paulo, Brazil. It was found that the rate of occurrence of adult diseases in the...
read more[#2001-12] Cholesterol-lowering effects of maitake (Grifola frondosa) fiber, shiitake (Lentinus edodes) fiber, and enokitake (Flammulina velutipes) fiber in rats, M. Fukushima et al.
Cholesterol-lowering effects of maitake (Grifola frondosa) fiber, shiitake (Lentinus edodes) fiber, and enokitake (Flammulina velutipes) fiber in rats Fukushima M, Ohashi T, Fujiwara Y, Sonoyama K, Nakano M. Department of Bioresource Science, Obihiro University of Agriculture and Veterinary Medicine The effects of mushroom fibers on serum cholesterol and hepatic low-density lipoprotein (LDL) receptor mRNA in rats were investigated. Rats were fed a cholesterol-free diet with 50 g/kg cellulose powder (CP), 50 g/kg maitake (Grifola frondosa)...
read more[#2001-11] Maitake (Grifola frondosa) improve glucose tolerance of experimental diabetic rats, H. Horio et al.
Maitake (Grifola frondosa) improve glucose tolerance of experimental diabetic rats Horio H, Ohtsuru M. Department of Food Science and Nutrition, Faculty of Home Economics, Nishikyushu University We have previously reported that rats with diabetes induced by injecting streptozotocin into neonates showed remarkably lower blood glucose, urine volume, and glucosuria after administration of Maitake (Grifola frondosa). In the present study, we investigated the effects of Maitake on insulin concentration, organ weight, serum composition, and islets...
read more[#2001-10] Nitric oxide-mediated antitumor activity induced by the extract from Grifola frondosa (Maitake mushroom) in a macrophage cell line, RAW264.7, I. Sanzen et al.
Nitric oxide-mediated antitumor activity induced by the extract from Grifola frondosa (Maitake mushroom) in a macrophage cell line, RAW264.7 Sanzen I, Imanishi N, Takamatsu N, Konosu S, Mantani N, Terasawa K, Tazawa K, Odaira Y, Watanabe M, Takeyama M, Ochiai H. Dept. of Clinical Nursing, Faculty of Medicine, Toyama Medical and Pharmaceutical University We have investigated D-fraction (MDF) extracted from Grifola frondosa ( Maitake mushroom) on the inducible nitric oxide synthase (iNOS)-mediated nitric oxide (NO) production in RAW264.7 (RAW)...
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