Effects of Lentinus edodes, Grifola frondosa and Pleurotus ostreatus administration on cancer outbreak, and activities of macrophages and lymphocytes in mice treated with a carcinogen, N-butyl-N-butanolnitrosoamine Kurashige S, Akuzawa Y, Endo F. Department of Laboratory Sciences, Gunma University School of Health Sciences ICR mice were treated with a carcinogen, N-butyl-N’-butanolnitrosoamine (BBN), every day for 8 consecutive weeks and the effects of oral administration of edible mushrooms on the induction of urinary bladder carcinoma...
read moreEffect of the Basidiomycete Poria cocos on Experimental Dermatitis and Other Inflammatory Conditions Maria Jesus CUELLAR, Rosa Maria GINER, Maria del Carmen RECIO, Maria Jose JUST, Salvador MANEZ,* and Jose Luis Rios Departament de Farmacologia, Facultat de Farmacia, Universitat de Valencia, Valencia, Spain. The hydroalcoholic extract from Poria cocos was examined for oral and topical anti-inflammatory activities. It proved to be active against carrageenan, arachidonic acid, tetradecanoyl phorbol acetate (TPA) acute edemas, TPA chronic...
read moreAnti-hyperliposis effect of maitake fruit body (Grifola frondosa) Kubo K, Nanba H. Department of Microbial Chemistry, Kobe Pharmaceutical University Experimental rat models (5-week-old Sprague-Dawley rats) with hyperlipemia were prepared by feeding high-cholesterol feed containing sodium cholate and casein as a protein source. Dried maitake (Grifola frondosa) powder was mixed with the basic high-cholesterol feed and the serum lipids were periodically measured. Values of cholesterol, triglyceride and phospholipid in serum of rats in the...
read moreSterol Constituents from the Fruit Bodies of Grifola frondosa Ishizuka, T, Yaoita, Y, Kikuchi, M Tohoku College of Pharmacy Four new sterols, 5α, 6α-epoxy-(22E, 24R)-ergosta-8 (14), 22-diene-3β, 7β-diol (1), (22E, 24R)-ergosta – 8,22-diene-3β,5α,6β,7α-tetrol (2), (22E,24R)-ergosta-7,9(11), 22-triene-3β,5α,6β-triol (3) and 3β,5α,6β-trihydroxy-(22E,24R)-ergost-22-en-7-one (4), have been isolated from the fruit bodies of Grifola frondosa ( maitake ) together with fourteen known ones (5-18), of which two (5 and 6) are reported...
read moreNitric Oxide Synthesis in Murine Peritoneal Macrophages by Fungal β-Glucans Tomoe HASHIMOTO, Naohito OHNO, Yoshiyuki ADACHI, and Toshiro YADOMAE* Maitake Laboratory of Immunopharmacology of Microbial Products, Tokyo University of Pharmacy and Life Science, Japan. Fungal β-glucans have abilities to induce NO (nitric oxide) synthesis by macrophages in vivo, and the intensity of NO synthesis significantly varied dependent on the structure of β-glucans. The molecular mechanism of NO synthesis by β-glucans, however, has not been clarified in...
read moreEffect of Maitake D-Fraction on Cancer Prevention Nanba, H Kubo, K Department of Microbial Chemistry, Kobe Pharmaceutical University In this paper, the author investigates whether D-fraction is effective against chemically-induced cancer and against metastasis or recrudescence of MM-46 breast cancer. The known carcinogen, methylcholanthrene, was injected into mice. Subsequently, D-fraction or saline was administered. In the D-fraction-treated mice, carcinogenesis occurred in 31% of cases relative to 93% of cases in the control. In a similar...
read moreMaitake D-Fraction: Healing and Preventive Potential for Cancer Nanba, H Kobe Pharmaceutical University, Japan Author has been studying medicinal mushrooms for the last 15 years and has reported that of all mushrooms studied, Maitake Mushroom (Grifola frondosa) has the strongest activity in tumor growth inhibition both in administered orally and intraperitoneally. In this report, Maitake extract D-fraction was investigated to determine its effectiveness not only on the inhibition against tumors already growing, but also on the inhibition of...
read moreLeukocyte activation by (1-3)-β-D glucans Yoshiyuki AdachiCA, Mitsuhiro Okazaki, Naohito Ohno and Toshiro Yadomae We studied the activities of several kinds of β-glucans, including sonifilan, grifolan, Sclerotinia sclerotiorum glucan, laminarin and zymosan, on macrophages. Pre-culture of macrophages with inactive β-glucans rendered the cells unresponsive to subsequent stimulation with grifolan, suggesting a specific pathway in the β -glucan structure. The importance of protein C and phosphorylation of mitogen-activated...
read moreAnti Diabetic Mechanism of Maitake (Grifola frondosa) Kubo, K, Nanba, H Department of Microbial Chemistry, Kobe Pharmaceutical University Glucose Tolerance Tests were conducted on KK-A mice, model animals of NIDDM (non-insulin dependent diabetes mellitus). The elevated blood glucose levels after 15 minutes and 30 minutes of Maitake-fed group were 0.64 times and 0.76 times those of the control group respectively, indicating inhibition of a significant blood glucose increase. Insulin receptor capability of liver cells then was examined using the...
read moreThe effect of maitake mushrooms on liver and serum lipids Kubo K, Nanba H. Department of Microbial Chemistry, Kobe Pharmaceutical University OBJECTIVE: To determine the efficacy of maitake mushrooms in inhibiting the elevation of liver and serum lipids in rats. DESIGN: Sprague-Dawley rats with hyperlipidemia were used to measure and compare the values of cholesterol, phospholipids, and triglycerides between cholesterol-fed rats and rats whose diets were fortified with 20% maitake mushroom dried powder. RESULTS: The values in maitake-fed...
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