REFERENCES
[#1996-03] Poria Nukaya, Haruo et al. Isolation of Inhibitors of TPA-Induced Mouse Ear Edema from Hoelen
Isolation of Inhibitors of TPA-Induced Mouse Ear Edema from Hoelen, Poria cocos Haruo NUKAYA, Hirokazu YAMASHIRO, Hirotatsu FUKAZAWA, Hitoshi ISHIDA, and Kuniro TSUJI School of Pharmaceutical Sciences, University of Shizuoka, Japan. Several anti-inflammatory substances are known to inhibit the action of tumor promoters in two-stage mouseskin carcinogenesis.”) Since anti-inflammatory activity may play an important role in the mechanism of anti-tumor promotion, we have searched for new anti-inflammatory substances among natural...
read more[#1996-02] Effect of beta-glucans on the nitric oxide synthesis by peritoneal macrophage in mice, N. Ohno et al.
Effect of beta-glucans on the nitric oxide synthesis by peritoneal macrophage in mice Ohno N, Egawa Y, Hashimoto T, Adachi Y, Yadomae T. School of Pharmacy, Tokyo University Pharmacy and Life Science, Japan. Nitric oxide (NO) is an important effector molecule on antimicrobial and antitumor effects of macrophages. (1 -> 3)-β-D-Glucan (β-glucan) is well known to show various immunopharmacological effects such as antimicrobial effect and antitumor effect by activating various points of host defense mechanisms. This paper deals with NO...
read more[#1996-01] Blood clearance of (1->3)-β-D-glucan in MRL lpr/lpr mice, Norihiko Miura et al.
Blood clearance of (1->3)-β-D-glucan in MRL lpr/lpr mice Miura NN, Ohno N, Aketagawa J, Tamura H, Tanaka S, Yadomae T. Laboratory for Immunopharmacology of Microbial Products, Tokyo University of Pharmacy and Life Science (1->3)-β-D-Glucans have a variety of biological and immunopharmacological properties, and they are used clinically as biological response modifiers (BRMs). Clinically, these glucans have often been used for long periods by multiple dosing. During studies on the clearance and metabolism of the glucans in mice, we have...
read more[#1995-08] Effects of Administration of Grifola frondosa on Glucose Tolerance and Glucosuria in Rats with Experimental Diabetes, H. Horio et al.
Effects of Administration of Grifola frondosa on Glucose Tolerance and Glucosuria in Rats with Experimental Diabetes Horio, H(a), Ohtsuru, M(b) a) Department of Nutrition, Faculty of Home Economics, Yamaguchi Women’s University, b) Department of Food and Nutrition, School of Human Life and Environmental Sciences, Mukogawa Women’s University The effects of Maitake (Grifola frondosa) on blood glucose levels in rats with streptozotocin-induced diabetes were investigated. Diabetic rats were produced by injecting 80 mg/kg streptozotocin...
read more[#1995-07] Antitumor Activity in Mice by β-Glucan Obtained from Grifola frondosa (Maitake), K. Adachi et al.
Antitumor Activity in Mice by β-Glucan Obtained from Grifola frondosa (Maitake) Adachi, K, Nanba, H, Kuroda, H Department of Microbiology, Kobe Women’s College of Pharmacy A polysaccharide (3-branched β-1,6-glucan MT-2) extracted from fruit bodies of Grifola frondosa ( Maitake ) showed an antitumor effect against mouse syngeneic tumors (MM-46 carcinoma and IMC-carcinoma). It not only directly activates various effector cells (microphages, natural killer cells, killer T cells, etc.) to attack tumor cells, but also potentiates the...
read more[#1995-06] Results of Non-Controlled Clinical Study for Various Cancer Patients Using Maitake D-Fraction, Hiroaki Nanba
Results of Non-Controlled Clinical Study for Various Cancer Patients Using Maitake D-Fraction Nanba, H Department of Microbial Chemistry, Kobe Pharmaceutical University A non-randomized clinical study using D-fraction and Maitake crude tablets was conducted to investigate if those are effective against cancer patients as they were against animals. The study was carried out with 165 patients with advanced cancer, stage III-IV, 25-65 years old. Most of the patients receiving the Maitake treatment claimed improvement of overall symptoms. The...
read more[#1995-05] Structure-activity relationship of (1->3)-β-D-glucans in the induction of cytokine production from macrophages, in vitro, Mitsuhiro Okazaki et al.
Structure-activity relationship of (1->3)-β-D-glucans in the induction of cytokine production from macrophages, in vitro Okazaki M, Adachi Y, Ohno N, Yadomae T. Laboratory of Immunopharmacology of Microbial Products School of Pharmacy, Tokyo University of Pharmacy and Life Science In a previous study, we reported that one of the gel-forming (1->3)-β-D-glucans, grifolan (from Maitake Grifola frondosa, GRN), stimulated cytokine production from macrophages in vitro. However, several other gel-forming (1->3)-β-D-glucans, such as...
read more[#1995-04] Maitake: Grifolan-Ohno, Naohito et al ‘Grifolan’
Enhancement of LPS triggered TNF-α (tumor necrosis factor-α) production by (1->3)-β-D-glucans in mice Ohno N, Asada N, Adachi Y, Yadomae T. Tokyo College of Pharmacy Effects of (1->3)-β-D-glucans on tumor necrosis factor-α (TNF-α ) production in mice in vivo were investigated with or without triggering stimulation of lipopolysaccharide (LPS). Administration of grifolan (GRN) (100-250 μg/mouse) obtained from Grifola frondosa ( maitake ), did not elevate the TNF-α concentration in serum, but significantly elevated LPS (10...
read more[#1995-03] Characterization of a Thermostable Lysine-Specific Metalloendereptidase from the Fruiting Bodies of a Basidiomycete, Grifola frondosa, Takashi Nonaka et al.
Characterization of a Thermostable Lysine-Specific Metalloendereptidase from the Fruiting Bodies of a Basidiomycete, Grifola frondosa Takashi Nonaka, Hiroko Ishikawa, Yoichi Tsumuraya, Yohichi Hashimoto, Naoshi Dohmae, and Koji Takio Department of Biochemistry, Faculty of Science, Saitama University, Saitama, Japan; and Division of Biomolecular Characterization, The Institute of Physical and Chemical Research (RIKEN), Saitama, Japan A zinc-metalloendopeptidase, MEP, capable of catalyzing specific cleavage of acyl-lysine bonds...
read more[#1995-02] Inactivation of (1-3)-β-D-Glucan in Mice, Toshihide Miyura et al.
Inactivation of (1-3)-β-D-Glucan in Mice Toshihide MIURA, Naohito OHNO, Masahiro SUDA, Noriko N. MIURA, Shigehiko SHIMADA, and Toshiro YADOMAE Tokyo University of Pharmacy and Life Science (formerly Tokyo College of Pharmacy), Tokyo Japan and Kitasato University Hospital, Department of Pharmacy, Kanagawa, Japan. Intraperitoneally or intravenously administered (1–>3)-β-D-glucan remained in the liver and spleen, for a long time without major structural changes, but the priming activity to lipopolysaccharide (LPS)-triggered tumor...
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