REFERENCES
[#1987-01] The Chemical Structure of an Antitumor Polysaccharide in Fruit Bodies of Grifola frondosa (Maitake), Hiroaki Nanba et al.
The Chemical Structure of an Antitumor Polysaccharide in Fruit Bodies of Grifola frondosa (Maitake) Nanba, H, Hamaguchi, A, Kuroda, H Laboratory of Microbiology, Kobe Women’s College of Pharmacy A polysaccharide was extracted from fruit bodies of Grifola frondosa ( maitake ), and the chemical structure and antitumor activity was studied. The extracted polysaccharide could be hydrolyzed by beta-glucanase into glucose, indicating it to be a beta-glucan. The sample gave methyl 2,3,4,6-tetra-O-methyl 2,4,6-tri-O-, methyl2,3,4-tri-O- and...
read more[#1986-09] Maitake: Ohno, Naohito et al ‘Phagocytic System’
Effect of Activation or Blockade of the Phagocytic System on the Antitumor Activity of Grifolan NAOHITO OHNO,a MAMI HAYASHI,a IWAO SUZUKI,a SHOZO OIKAWA,b KICHIRO SATO,b YOSHIYUKI Suzum,b and TOSHIRO YADOMAE” Tokyo College of Pharmacy,’ Horinouchi, Hachioji, Tokyo 192-03, Japan and Nippon Beet Sugar Mfg., Co., Ltd.,”Chuo-ku, Tokyo 104, Japan The effect of activation or blockade of the phagocytic system on the antitumor activity of grifolan (from maitake ) was investigated. The activity of grifolan was abrogated by treatment...
read more[#1986-08] Maitake and other mushrooms: Ohno, Naohito et al ‘Grifolan 5′
Carbon-13 Nuclear Magnetic Resonance Spectroscopy of Some Edible Mushrooms NAOHITO OHNO, IWAO SUZUKI, and TOSHIRO YADOMAE* Tokyo College of Pharmacy, Horinouchi, Hachioji, Tokyo 192-03, Japan In this paper, carbon-13 nuclear magnetic resonance (13C-NMR) spectra of some edible Mushrooms, Grifola frondosa ( maitake ), Lentinus edodes, Flammulina velutipes, Pholiota nameko, Agaricus bisporus, Lyophyllum cinerascens, Lyophyllum aggregatum, and Peziza vesiculosa, as aqueous suspensions were measured and the glucan compositions in these mushrooms...
read more[#1986-07] Characterization of the Antitumor Glucan Obtained from Liquid-Cultured Grifola frondosa, N. Ohno et al.
Characterization of the Antitumor Glucan Obtained from Liquid-Cultured Grifola frondosa Ohno, N (a), Adachi, Y (a), Suzuki, I (a), Sato, K (b), Oikawa, S (b), Yadomae, T(a) a) Tokyo College of Pharmacy, b) Nippon Beet Sugar Mfg. Co. Ltd. Chemical characterization of the extracts, and purification and structural characterization of an antitumor glucan obtained from liquid-cultured mycelium of Grifola frondosa ( maitake ) are described in this paper. The mycelium (13 g dry weight/l culture) was extracted successively with hot water (LMHW, 14.9...
read more[#1986-06] Two Different Conformations of Antitumor Glucans Obtained from Grifola frondosa, Naohito Ohno et al.
Two Different Conformations of Antitumor Glucans Obtained from Grifola frondosa Ohno, N (a), Adachi, A (a), Suzuki, A (a), Oikawa, S (b), Sato, K (b), Suzuki, Y (b), Ohsawa, M (b), Yadomae, T (a) a) Tokyo College of Pharmacy, b) Nippon Beet Sugar Mfg. Co. Ltd. Several antitumor glucan fractions obtained by various extraction procedures from Grifola frondosa ( maitake ) were compared by solution and solid (cross polarization, magic angle spinning (CP/MAS)) carbon-13 nuclear magnetic resonance (13C-NMR) spectroscopy. The fractions prepared...
read more[#1986-05] Antitumor activity of a β-1,3-glucan obtained from liquid cultured mycelium of Grifola frondosa, Naohito Ohno et al.
Antitumor activity of a β-1,3-glucan obtained from liquid cultured mycelium of Grifola frondosa Ohno N, Adachi Y, Suzuki I, Oikawa S, Sato K, Ohsawa M, Yadomae T. Tokyo College of Pharmacy The antitumor activity of a branched β-1,3-glucan “grifolan LE” purified from liquid cultures of Grifola frondosa ( maitake ) (Ohno et al. Chem. Pharm. Bull., 34, 1709-1715, 1986) was examined on an allogeneic murine tumor system. By intraperitoneal (i.p.) administration (100-200 μg/mouse/d X 5) at days 1 to 9 from the tumor transplantation,...
read more[#1986-04] Effect of Activation or Blockade of the Phagocytic System on the Antitumor Activity of Grifolan, Naohito Ohno et al.
Effect of Activation or Blockade of the Phagocytic System on the Antitumor Activity of Grifolan NAOHITO OHNO,a MAMI HAYASHI,a IWAO SUZUKI,a SHOZO OIKAWA,b KICHIRO SATO,b YOSHIYUKI Suzuiu,b and TOSHIRO YADOMAE*‘ a Tokyo College of Pharmacy,a and Nippon Beet Sugar Mfg., Co., Ltd.,b The effect of activation or blockade of the phagocytic system on the antitumor activity of grifolan from Maitake was investigated. The activity of grifolan was abrogated by treatment of mice with a blocker of the phagocytic system, i.e., carrageenan,...
read more[#1986-03] Fractionation of Acidic Antitumor β-Glucan of Grifola frondosa by Anion-Exchange Chromatography Using Urea Solutions of Low and High Ionic Strengths, Naohito Ohno et al.
Fractionation of Acidic Antitumor β-Glucan of Grifola frondosa by Anion-Exchange Chromatography Using Urea Solutions of Low and High Ionic Strengths NAOHITO OHNO,a KAZUYOSHI IINO,a SHOZO OEKAWA,b KICHIRO SATO,b MASUMI OHSAWA,b and TOSHIRO YADOMAE*‘ a Tokyo College of Pharmacy,’ Horinouchi, Hachioji, Tokyo 192-03, Japan and Nippon Beet Sugar Mfg. Co., Ltd.,’ Kyobashi, Chuo-ku, Tokyo 104, Japan The antitumor β-glucan from the fruit body of Grifola frondosa ( Maitake ) was resolved by DEAE Sephadex chromatography into...
read more[#1986-02] Effect of Glucans on the Antitumor Activity of Grifolan, Naohito Ohno et al.
Chem. Pharm. Bull. 1986; 34(5): 2149-54. Effect of Glucans on the Antitumor Activity of Grifolan Ohno, N(a), Hayashi, M (a), Iino, K (a), Suzuki, I (a), Oikawa, S (b), Sato, K (b), Suzuki, Y (b), Yadomae , T (a) a)Tokyo College of Pharmacy, b) Nippon Beet Sugar Mfg. Co. Ltd. The effects of antitumor active [β-1,3-glucan(grifolan)] and inactive [β-1,6-(islandican), α-1,4-(starch)]glucans in mice were compared. β-1,6-Glucan enhanced the antitumor activity of grifolan, whereas α-1,4-glucan showed a suppressive effect on the antitumor...
read more[#1986-01] Fractionation and Characterization of Antitumor Polysaccharides from Maitake, Grifola frondosa, T. Mizuno et al.
Fractionation and Characterization of Antitumor Polysaccharides from Maitake, Grifola frondosa Mizuno, T, Ohsawa, K, Hagiwara, N, Kuboyama, R Dept. of Agricultural Chemistry, Faculty of Agriculture, Shizuoka University Three groups of polysaccharides from the edible mushroom, “Maitake”, the cultured fruiting body of Grifola frondosa, were extracted with hot water, 3% NH4-oxalate (100o C), and 5% sodium hydroxide solution (30o C ) in this order. The three fractions, FI, FII, and FIII, were divided into several sub-fractions using...
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