REFERENCES
[#1989-01] Maitake – Physiochemical properties and antitumor activities of chemically modified derivatives of antitumor glucan “grifolan LE” from Grifola frondosa, Y. Adachi et al.
Maitake - Physiochemical properties and antitumor activities of chemically modified derivatives of antitumor glucan “grifolan LE” from Grifola frondosa Adachi Y, Ohno N, Ohsawa M, Sato K, Oikawa S, Yadomae T. Laboratory of Immunopharmacology of Microbial Products, Tokyo College of Pharmacy Antitumor glucan, grifolan LE (GRN LE), from Grifola frondosa ( maitake ) was chemically modified to examine the structure-function relationship of the products. Modification by periodate, borohydride and acid hydrolysis of side chains of GRN...
read more[#1988-03] Distribution of Grifolan NMF-5N (I/B), a Chemically Modified Antitumor β- Glucan in Mice, T. Takeyama et al.
Distribution of Grifolan NMF-5N (I/B), a Chemically Modified Antitumor β- Glucan in Mice Takahiro TAKEYAMA, Iwao SUZUKI, Naohito OHNO,* Shozo OIKAWA, Kichiro SATO, Masumi OHSAWA,** and Toshiro YADOMAE* Tokyo College of Pharmacy, * Horinouchi, Hachioji, Tokyo, 192-03, Japan and Nippon Beet Sugar Mfg., Co., Ltd., ** Chuo-ku, Tokyo, 104, Japan The distribution of a 3H-labeled chemically modified antitumor β-glucan, grifolan ( from maitake ) NMF-5N (I/B), in various tissues after an injection into mice was examined in order to obtain...
read more[#1988-02] Antitumor Activity Exhibited by Orally Administered Extract from Fruit Body of Grifola frondosa (Maitake), I. Hishida et al.
Antitumor Activity Exhibited by Orally Administered Extract from Fruit Body of Grifola frondosa (Maitake) Hishida, I, Nanba, H, Kuroda, H Laboratory of Microbiology, Kobe Women’s College of Pharmacy, Japan The acid-insoluble, alkali-soluble, hot water-extractable polymer (a polysaccharide containing approximately 30% of protein; D-fraction) obtained from the fruit bodies of Grifola frondosa ( maitake ) exhibited antitumor activities against allogenic and syngeneic tumors on oral administration to mice. Winn assay conducted to examine the...
read more[#1988-01] Blood Pressure-Lowering Activity Present in the Fruit Body of Grifola frondosa (Maitake), K. Adachi et al.
Blood Pressure-Lowering Activity Present in the Fruit Body of Grifola frondosa (Maitake) Adachi, K, Nanba, H, Otsuka, M, Kuroda, H Department of Microbiology, Kobe Women’s College of Pharmacy The fruit body of Grifola frondosa (maitake), Basidiomycetes, was confirmed to contain a substance with blood pressure-lowering activity. When powdered fruit body of maitake was given orally to spontaneously hypertensive rats (SHR), blood pressure reduction was observed, in contrast to the control group in which the blood pressure increased with...
read more[#1987-09] Effect of Shiitake (Lentinus edodes) and Maitake (Grifola frondosa) Mushrooms on Blood Pressure and Plasma Lipids of Spontaneously Hypertensive Rats, Y. Kabir et al.
Effect of Shiitake (Lentinus edodes) and Maitake (Grifola frondosa) Mushrooms on Blood Pressure and Plasma Lipids of Spontaneously Hypertensive Rats Kabir, Y, Yamaguchi, M, Kimura, S Laboratory of Nutrition, Department of Food Chemistry, Tohoku University To study the effect of Shiitake (Lentinus edodes) and Maitake (Grifola frondosa) on hypertension, spontaneously hypertensive rats were fed a diet containing 5% mushroom powder and 0.5% NaCl solution as drinking water for 9 weeks. The dietary mushrooms decreased the blood pressure. The plasma...
read more[#1987-08] Antitumor Activities of Edible Mushrooms by Oral Administration, K. Mori et al.
Antitumor Activities of Edible Mushrooms by Oral Administration Mori, K (a), Toyomasu, H (a), Nanba, H (b), Kuroda, H (b) a) The Mushroom Research Institute of Japan, b) Kobe Women’s College of Pharmacy Antitumor activities of edible mushrooms were investigated by breeding mice with the feed containing 10-30% (w/w) powdered fruit bodies. In allogeneic tumor systems (Sarcoma 180 in ICR mice), the tumor growth was suppressed to 40-50% by oral administration of edible mushrooms. While in syngeneic systems (B-16 melanoma or Lewis Lung...
read more[#1987-07] Host-mediated antitumor effect of grifolan NMF-5N, a polysaccharide obtained from Grifola frondosa (maitake), T. Takeyama et al.
Host-mediated antitumor effect of grifolan NMF-5N, a polysaccharide obtained from Grifola frondosa ( maitake ) Takeyama T, Suzuki I, Ohno N, Oikawa S, Sato K, Ohsawa M, Yadomae T. Tokyo College of Pharmacy The antitumor mechanism of grifolan NMF-5N, a β-1,3-glucan obtained from mycelia of Grifola frondosa, was examined. Grifolan NMF-5N did not show direct cytocidal effect on cultured tumor cells. However, intraperitoneal injection of grifolan NMF-5N increased the number of peritoneal exudate cells and peritoneal adherent cells which showed...
read more[#1987-06] ANTITUMOR EFFECT OF POLYSACCHARIDE GRIFOLAN NMF-5N ON SYNGENEIC TUMOR IN MICE, I. Suzuki et al.
ANTITUMOR EFFECT OF POLYSACCHARIDE GRIFOLAN NMF-5N ON SYNGENEIC TUMOR IN MICE IWAO SUZUKI,* TAKAHIRO TAKEYAMA,* NAOHITO OHNO,* SHOZO OIKAWA,** KICHIRO SATO,** YOSHIYUKI SUZUKI,** AND TOSHIRO YADOMAE* Tokyo College of Pharmacy, * Horinouchi, Hachioji, Tokyo, 192-03, Japan and Nippon Beet Sugar Mfg., Co. Ltd., ** Chuo-ku, Tokyo, 104, Japan Antitumor activity of grifolan (from maitake ) NMF-5N, a β-1,3-glucan obtained from mycelia of Grifola frondosa, was examined. Grifolan NMF-5N showed antitumor activities in allogeneic and syngeneic...
read more[[#1987-05] Conformational Changes of the Two Different Conformers of Grifolan in Sodium Hydroxide, Urea or Dimethylsulfoxide Solution, N. Ohno et al.
Conformational Changes of the Two Different Conformers of Grifolan in Sodium Hydroxide, Urea or Dimethylsulfoxide Solution Ohno, N (a), Adachi, Y(a), Ohsawa, M (b), Sato, K (b),Oikawa, S (b), Yadomae, T (b) a) Tokyo College of Pharmacy, b) Nippon Beet Sugar Mfg. Co. Ltd. Grifolan is an antitumor (1–>3)-β-D-glucan with a β-glucosyl substitution at C-6 of every three main chain units, and is produced by Grifola frondosa ( maitake ). Grifolan possesses two different solid-state conformations, N (native) and H (helix) (N. Ohno et al.,...
read more[#1987-02] Potentiation of Host-Mediated Antitumor Activity in Mice by Beta-Glucan Obtained from Grifola frondosa (Maitake), K. Adachi et al.
Potentiation of Host-Mediated Antitumor Activity in Mice by Beta-Glucan Obtained from Grifola frondosa (Maitake) Adachi, K, Nanba, H, Kuroda, H Department of Microbiology, Kobe Women’s College of Pharmacy A polysaccharide (3-branched β-1,6-glucan MT-2) extracted from fruit bodies of Grifola frondosa ( maitake ) showed an antitumor effect against mouse syngeneic tumors (MM-46 carcinoma and IMC-carcinoma). It not only directly activates various effector cells (macrophages, Natural Killer cells, killer T-cells, etc.) to attack tumor cells,...
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