REFERENCES
[#2017-02] Maitake He, Xirui et al. Polysaccharides in Grifola frondosa mushroom and their health promoting properties, A review
Grifola frondosa is a widely consumed edible and medicinal fungus, Ancient books record that it can boost qi and fortify the spleen, moisten the lung and protect the liver. Modern people mainly use it to assist in the treatment of diabetes mellitus and various cancers. Over the past three decades, G. frondosa polysaccharides were shown to possess various promising bioactivities, mainly including anti-tumor and immunomodulation, anti-oxidation, anti-hyperglycemia, and meanwhile can effectively act on the skin and hematopoietic stem cells. The...
read more[#2017-01] Lion’s Mane Phan, Chia-Wei et al Edible and Medicinal Mushrooms – Emerging Brain Food for the Mitigation of Neurodegenerative Diseases
There is an exponential increase in dementia in old age at a global level because of increasing life expectancy. The prevalence of neurodegenerative diseases such as dementia and Alzheimer’s disease (AD) will continue to rise steadily, and is expected to reach 42 million cases worldwide in 2020. Despite the advancement of medication, the management of these diseases remains largely ineffective. Therefore, it is vital to explore novel nature-based nutraceuticals to mitigate AD and other age-related neurodegenerative disorders. Mushrooms...
read more[#2016-10] Maitake Erjavec, Igor et al. Mushroom Extracts Decrease Bone Resorption and Improve Bone Formation
ABSTRACT: Mushroom extracts have shown promising effects in the treatment of cancer and various chronic diseases. Osteoporosis is considered one of the most widespread chronic diseases, for which currently available therapies show mixed results. In this research we investigated the in vitro effects of water extracts of the culinary-medicinal mushrooms Trametes versicolor, Grifola frondosa, Lentinus edodes, and Pleurotus ostreatus on a MC3T3-E1 mouse osteoblast-like cell line, primary rat osteoblasts, and primary rat osteoclasts. In an...
read more[#2016-09] Meshima Konno, Sensuke et al. Alternative Therapeutic Approach to Urothelial Cell Carcinoma with Medicinal Mushroom Extracts
Abstract Severe side effects from chemotherapy or immunotherapy often limit their clinical utility in urothelial cell carcinoma of the bladder. To explore alternative therapies, we were particularly interested in one of medicinal mushrooms called Phellinus linteus (PL) with antitumor/anticancer activity. We investigated possible anticancer effects of three distinct extracts or fractions of PL using an urothelial cell carcinoma (UCC) model in vitro. Those fractions included PL-I (crude extract), PL-II (water-extracted), and PL-III...
read more[#2016-08] Maitake Bao, Hongkun et al. Grifola frondosa GF produces significant antidepressant effects involving AMPA receptor activation in mice
In this paper, we investigated the antidepressant effects of the medical mushroom GF. We found that (1) GF demonstrated antidepressant effects in the TST and FST after 1-day or 5-day treatments; (2) GF led to no hyperactive effects in the OFT; (3) The antidepressant effects of GF were stronger compared to the other medical mushroom PO; (4) AMPA receptor-specific antagonist GYKI 52466 was able to block the antidepressant effects of GF, suggesting that AMPA receptors are involved in the antidepressant effects of GF.
read more[#2016-07] Poria Konno, Sensuke et al. Antioxidant and Renoprotective Effects of Mushroom Extract; Implication in Prevention of Nephrolithiasis
The present study shows that PE has antioxidant and renoprotective effects against severe oxidative stress exerted by H2O2 or COM (CaOx monohydrate). Such oxidative stress would inhibit glycolysis, deplete cellular ATP, and also interfere with the cell cycle progression (a G1 cell cycle arrest). These adverse effects may account for the resulting cell viability reduction but could be effectively prevented by PE. Therefore, PE is a promising agent with antioxidant activity, capable of protecting renal cells from oxidative assault, and...
read more[#2016-04] Royal Agaricus Therkelsen, S. P. et al. Effect of the Medicinal Agaricus blazei Murill-based Mushroom Extract
The results from this single-blinded randomized clinical trial shows significant improvement on symptoms, for both genders, in the AndoSanTM group, but no significant differences between the study groups. The results on fatigue, HRQoL, fecal calprotectin and blood samples were quite similar compared with placebo. The patients did not report any harms or unintended effects of AndoSanTM. CD patients with mild to moderate symptoms may have beneficiary effects of AndoSanTM as a safe supplement in addition to conventional medication.
read more[#2016-03] Lion’s Mane Cheng, Jai-Hong et al High Molecular weight of polysaccharides from Hericium erinaceus against amyloiod beta-induced neurotoxic
Hericium erinaceus (HE) is a well-known mushroom in traditional Chinese food and medicine. HE extracts from the fruiting body and mycelia not only exhibit immunomodulatory, antimutagenic and antitumor activity but also have neuroprotective properties. Here, we purified HE polysaccharides (HEPS), composed of two high molecular weight polysaccharides (1.7 × 105 Da and 1.1 × 105 Da), and evaluated their protective effects on amyloid beta (Aβ)-induced neurotoxicity in rat pheochromocytoma PC12 cells. Methods: HEPS were prepared and...
read more[#2016-02] Cordyceps Lin, Bao-quin Cordyceps as an Herbal Drug
Cordyceps is the composite of a genus of fungus that grows on the larva of insects. To date, more than 350 Cordyceps-related species have been found worldwide based on fungus and/or insect host. However, since 1964, only Cordyceps sinensis has been recorded officially as an herbal drug in Chinese pharmacopoeia. C. sinensis, known as Dongchongxiacao (winter-worm summer-grass) in Chinese, is one of the most famous traditional Chinese medicines and medicinal mushrooms. The fungus attacks the larva of some species of insects (Fam. Hepialidae), and...
read more[#2016-01] Reishi Cai, Zhe et al. Anti-inflammatory activities of Ganoderma for lupus
Abstract Background: Ganoderma lucidum (Lingzhi; LZ) and San-Miao-San (SMS) are Chinese medicines (CMs) used to treat inflammatory ailments and numbing syndrome/arthralgia syndrome (Bi Zheng), respectively. Given that the main symptoms of systemic lupus erythematosus (SLE) include inflammation of the joints, joint pain, edema and palpitations of the heart because of problems associated with Bi Zheng, it was envisaged that LZ and SMS could be used as potential treatments for this autoimmune disease. This study aims to investigate the...
read more